Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation 4

• Material Type: 博士論文
• Title: Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation
• Volume: 36 4
• Author/Editor: Uddin, Mohammad Khaja Mafij
• Author Heading: Uddin, Mohammad Khaja Mafij
• Publication, Distribution, etc.: Biomedical Research Press
• Publication Date: 2015
• Publication Date (W3CDTF): 2015
• Alternative Title: 咽頭弓の間葉で発現するFoxc2は大動脈弓の動脈再構築と心室中隔形成に重要である
• Periodical title: Biomedical Research
• Degree grantor/type: 浜松医科大学
• Date Granted: 2016-03-14
• Date Granted (W3CDTF): 2016-03-14
• Dissertation Number: 甲第725号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第725号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; The forkhead box C2 (Foxc2) protein is a member of the forkhead/winged helix transcription factor family and plays an essential role in cardiovascular development. Previous studies showed that Foxc2 null mouse embryos die during midgestation or just after birth with severe cardiovascular defects, including interruption, coarctation of the aortic arch and ventricular septal defects. These are also seen in human congenital heart disease. However, the tissue specific role of Foxc2 in aortic arch remodelling is not yet fully understood. Here we show that Foxc2 is expressed in a restricted pattern in several cell populations, including the mesenchyme and endothelium of pharyngeal arch arteries, which are important for cardiovascular development. In this study, we use a conditional knockout approach to examine the tissue specific role of Foxc2 in aortic arch remodelling. We demonstrate that mouse embryos lacking Foxc2 in Nkx2.5-expressing mesenchyme and endothelium of pharyngeal arch arteries display aortic arch interruption type B and ventricular septal defects. In contrast, conditional deletion of Foxc2 in Tie2-expressing endothelial cells does not result in aortic arch or ventricular septal defects, but does result in embryonic lethality due to peripheral oedema. Our data therefore provide for a detailed understanding of the role of mesenchymal Foxc2 in aortic arch remodelling and in the development of ventricular septum.
• DOI: info:doi/10.2220/biomedres.36.235; https://doi.org/info:doi/10.2220/biomedres.36.235
• Persistent ID (NDL): info:ndljp/pid/10300483; https://dl.ndl.go.jp/pid/10300483
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-02-09T20:08:30+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/3146; https://hama-med.repo.nii.ac.jp/records/3004
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2018-10-04 再収集

2023-03-02 再収集

2023-10-11 再収集

2023-12-09 再収集