Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans

• Material Type: 博士論文
• Title: Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans
• Author/Editor: Sakaue, Yuuki
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2016-09-20
• Publication Date (W3CDTF): 2016-09-20
• Alternative Title: Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans; Streptococcus mutansに対するMagnololおよびHonokiolの殺菌ならびに抗バイオフィルム効果
• Degree grantor/type: 新潟大学
• Date Granted: 2016-09-20
• Date Granted (W3CDTF): 2016-09-20
• Dissertation Number: 甲第4224号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第4224号
• Text Language Code: eng
• Subject Heading: honokiol; magnolia bark; magnolol; Streptococcus mutans
• Note (General): Dental caries affects people of all ages and is a worldwide health concern. Streptococcus mutans is a major cariogenic bacterium because of its ability to form biofilm and induce an acidic environment. In this study, the antibacterial activities of magnolol and honokiol, the main constituents of the bark of\ magnolia plants, toward planktonic cell and biofilm of S. mutans were examined and compared with those of chlorhexidine. The minimal inhibitory concentrations of magnolol, honokiol and chlorhexidine for S. mutans were 10, 10 and 0.25mg/mL, respectively. In addition, each agent showed bactericidal\ activity against S.mutans planktonic cells and inhibited biofilmformationin a dose- andtime-dependent manner.Magnolol (50mg/mL) had greater bactericidal activity against S. mutans biofilm than honokiol (50mg/mL) and chlorhexidine (500mg/mL) at 5min after exposure, while all showed scant activity\ against biofilm at 30 s. Furthermore; chlorhexidine (0.5–500mg/mL) exhibited high cellular toxicity for the gingival epithelial cell lineCa9-22 at 1 hr,whereasmagnolol (50mg/mL) and honokiol (50mg/mL) did not. Thus; it was found thatmagnolol has antimicrobial activities against planktonic and biofilm cells of S. mutans. Magnolol may be a candidate for prevention and management of dental caries.; 学位の種類: 博士（歯学）. 報告番号: 甲第4224号. 学位記番号: 新大院博（歯）甲第366号. 学位授与年月日: 平成28年9月20日; Microbiology and Immunology 2016; 60: 10–16; 新大院博（歯）甲第366号; 元資料の権利情報 : © 2015 The Societies and John Wiley & Sons Australia, Ltd
• DOI: info:doi/10.1111/1348-0421.12343; https://doi.org/info:doi/10.1111/1348-0421.12343
• Persistent ID (NDL): info:ndljp/pid/10310726; https://dl.ndl.go.jp/pid/10310726
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-03-02T13:20:07+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/45110
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp