血球貪食を行う単球由来樹状細胞は過剰な免疫応答を制御する

Persistent ID (NDL): info:ndljp/pid/10318040

Material type: 博士論文

Author: 大八木, 秀明ほか

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Publication date: 2013-11-01

Material Format: Digital

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Name of awarding university/degree: 秋田大学,博士（医学）

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Note (General)：: Since immune responses simultaneously defend and injure the host, the immune system must be finely regulated to insure the host's survival. Here, we s...

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Material Type: 博士論文
Title: 血球貪食を行う単球由来樹状細胞は過剰な免疫応答を制御する
Author/Editor: 大八木, 秀明
Ohyagi, Hideaki
Author Heading: 大八木, 秀明
Ohyagi, Hideaki
Publication Date: 2013-11-01
Publication Date (W3CDTF): 2013-11-01
Alternative Title: Monocyte-derived Dendritic Cells Perform Hemophagocytosis to Fine-tune Excessive Immune Responses
Degree grantor/type: 秋田大学
Date Granted: 2013-09-25
Date Granted (W3CDTF): 2013-09-25
Dissertation Number: 甲第1060号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第1060号
Text Language Code: eng
Target Audience: 一般
Note (General): Since immune responses simultaneously defend and injure the host, the immune system must be finely regulated to insure the host's survival. Here, we show that when injected with high TLR ligand doses or infected with LCMV clone 13, which has a high viral turnover, inflammatory monocyte-derived dendritic cells (Mo-DCs) are induced to engulf apoptotic erythroid cells. In this process, called hemophagocytosis, extracellular ATP and phosphatidylserine (PS) serve as “find-me” and “eat-me” signals, respectively. Type I IFNs are necessary for both PS exposure on erythroid cells and the expression of PS receptors in the Mo-DCs. Importantly, hemophagocytosis is required for IL-10 production from Mo-DCs. Blocking hemophagocytosis or Mo-DC-derived IL-10 significantly increases CTL activity, tissue damage, and mortality in virus-infected hosts, suggesting that hemophagocytosis moderates immune responses to assure the host’s survival in vivo. This sheds light on the induction mechanisms and physiological relevance of hemophagocytosis in severe inflammatory and infectious diseases.
http://www.sciencedirect.com/science/article/pii/S107476131300349X
Persistent ID (NDL): info:ndljp/pid/10318040
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
Date Created (W3CDTF): 2017-02-16
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Related Material (URI): http://www.sciencedirect.com/science/article/pii/S107476131300349X
Periodical Title (URI): http://hdl.handle.net/10295/2331
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