Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide

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Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide

Persistent ID (NDL): info:ndljp/pid/10318060

Material type: 博士論文

Author: 石河, 軌久ほか

Publisher: -

Publication date: 2014-06-01

Material Format: Digital

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Name of awarding university/degree: 秋田大学,博士（医学）

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Note (General)：: Recurrence after chemotherapy is a major cause of cancer mortality: subsets of tumor cells evade initial chemotherapy or radiotherapy and survive to r...

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Material Type: 博士論文
Title: Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide
Author/Editor: 石河, 軌久
Ishiga, Norihisa
Author Heading: 石河, 軌久
Ishiga, Norihisa
Publication Date: 2014-06-01
Publication Date (W3CDTF): 2014-06-01
Alternative Title: サリノマイシン細胞周期の遅い細胞を含むメラノーマ・スフェロイドの三酸化ヒ素に対する効果を鋭敏化する
Degree grantor/type: 秋田大学
Date Granted: 2014-03-22
Date Granted (W3CDTF): 2014-03-22
Dissertation Number: 甲第1077号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第1077号
Text Language Code: eng
Target Audience: 一般
Note (General): Recurrence after chemotherapy is a major cause of cancer mortality: subsets of tumor cells evade initial chemotherapy or radiotherapy and survive to re-propagate the tumor. To develop a novel therapeutic approach for melanoma, we applied a non-adhesive culture system which developed spheroids mimicking the properties of melanoma in vivo. Subsequently, spheroids involved cells exhibiting clonogenic and slow-cycling properties in addition to chemotherapeutic resistance to doxorubicin. Interestingly, while treatment of spheroids with either salinomycin or As_2O_3 showed limiting effects, a combinatorial treatment was markedly superior to single treatment with each drug. Thus, melanoma spheroids could be a new platform for studying melanoma biology and are likely to provide a clinically relevant target for the novel chemotherapy.
http://hdl.handle.net/10295/2504
Persistent ID (NDL): info:ndljp/pid/10318060
https://dl.ndl.go.jp/pid/10318060
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
Date Created (W3CDTF): 2017-02-16
Format (IMT): PDF
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Related Material (URI): http://hdl.handle.net/10295/2504
Periodical Title (URI): http://hdl.handle.net/10295/2511
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