Anti-melanogenesis effect of Glechoma hederacea L. extract on B16 murine melanoma cells

Persistent ID (NDL): info:ndljp/pid/10318061

Material type: 博士論文

Author: 喬, 志偉ほか

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Publication date: 2014-06-01

Material Format: Digital

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Name of awarding university/degree: 秋田大学,博士（医学）

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Note (General)：: Glechoma hederacea L. (Labiatae) has been used in folk medicine to treat various ailments for centuries. We investigated the effects of G. hederacea e...

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Material Type: 博士論文
Title: Anti-melanogenesis effect of Glechoma hederacea L. extract on B16 murine melanoma cells
Author/Editor: 喬, 志偉
QIAO, ZHIWEI
Author Heading: 喬, 志偉
QIAO, ZHIWEI
Publication Date: 2014-06-01
Publication Date (W3CDTF): 2014-06-01
Alternative Title: マウスB16 メラノーマ細胞におけるカキドオシエキスによるメラニン生成の抑制
Degree grantor/type: 秋田大学
Date Granted: 2014-03-22
Date Granted (W3CDTF): 2014-03-22
Dissertation Number: 甲第1083号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第1083号
Text Language Code: eng
Subject Heading: melanogenesis
Glechoma hederacea
tyrosinase
tyrosinase-related protein
microphthalmia-associated transcription factor
Target Audience: 一般
Note (General): Glechoma hederacea L. (Labiatae) has been used in folk medicine to treat various ailments for centuries. We investigated the effects of G. hederacea extract on melanogenesis in B16 melanoma cells. It significantly reduced both the cellular melanin content and tyrosinase activity in a concentration-dependent manner. An MTT assay did not reveal any obvious cytotoxicity. Furthermore, we found that G. hederacea extract decreased tyrosinase and microphthalmia-associated transcription factor protein expression, but did not inhibit tyrosinase-related protein-1 and tyrosinase-related protein-2 expression. RT-PCR analysis indicated that the antimelanogenic effect of G. hederacea extract might be due to inhibition of tyrosinase gene transcription. Moreover, this effect is regulated via suppression of microphthalmia-associated transcription factor protein expression. Our data indicate that G. hederacea extract inhibits melanin synthesis in B16 melanoma cells but is not cytotoxic. Hence it might prove a useful therapeutic agent for treating hyperpigmentation and an effective component of whitening cosmetics.
DOI: info:doi/10.1271/bbb.120341
https://doi.org/info:doi/10.1271/bbb.120341
Persistent ID (NDL): info:ndljp/pid/10318061
https://dl.ndl.go.jp/pid/10318061
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
Date Created (W3CDTF): 2017-02-16
Format (IMT): PDF
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Periodical Title (URI): http://hdl.handle.net/10295/2514
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