Noninvasive detection of sleep/wake changes and cataplexy -like behaviors in orexin/ataxin-3 transgenicnarcoleptic mice across the disease onset

Persistent ID (NDL): info:ndljp/pid/10318132

Material type: 博士論文

Author: 佐藤, 雅俊ほか

Publisher: 秋田大学

Publication date: 2015-06-01

Material Format: Digital

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Name of awarding university/degree: 秋田大学,博士（医学）

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Note (General)：: Sleep and behavioral monitoring of young mice is necessary forunderstating the progress of these symptoms in congenital and acquireddiseases associate...

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Material Type: 博士論文
Title: Noninvasive detection of sleep/wake changes and cataplexy -like behaviors in orexin/ataxin-3 transgenicnarcoleptic mice across the disease onset
Author/Editor: 佐藤, 雅俊
SATO, Masatoshi
Author Heading: 佐藤, 雅俊
SATO, Masatoshi
Publication, Distribution, etc.: 秋田大学
Publication Date: 2015-06-01
Publication Date (W3CDTF): 2015-06-01
Alternative Title: 発症前後のナルコレプシーモデルマウスにおける睡眠覚醒変化とカタプレキシー様行動の非侵襲的解析
Degree grantor/type: 秋田大学
Date Granted: 2015-03-22
Date Granted (W3CDTF): 2015-03-22
Dissertation Number: 甲第1110号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第1110号
Text Language Code: eng
Target Audience: 一般
Note (General): Sleep and behavioral monitoring of young mice is necessary forunderstating the progress of these symptoms in congenital and acquireddiseases associated with sleep and movement disorders. In the current study,we have developed a non-invasive sleep monitoring system that identifies wakeand sleep of newborn mice using a simple piezoelectric transducer (PZT). Usingthis system, we have succeeded to detect age-dependent occurrences andchanges in sleep fragmentation of orexin/ataxin-3 narcoleptic mice (anarcoleptic mouse of model of postnatal hypocretin/orexin cell death) across thedisease onset. We also detected REM sleep/cataplexy patterns (i.e., immobilitywith clear heart bests [IMHB] signals due to the flaccid posture) by the PZTsystem, and found that sudden onset of REM sleep-like episodes specificallyoccur in narcoleptic, but not in wild type mice, suggesting that these episodesare likely to be cataplexy. In contrast, gradual onset of IMHB likely to reflectoccurrence of REM sleep.In summary, we have shown that the PZT system is useful as a noninvasivesleep and behavior monitoring system to analyze the developmentalaspects of sleep and movement disorders in mice models.
DOI: info:doi/10.1016/j.expneurol.2014.08.004
https://doi.org/info:doi/10.1016/j.expneurol.2014.08.004
Persistent ID (NDL): info:ndljp/pid/10318132
https://dl.ndl.go.jp/pid/10318132
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
Date Created (W3CDTF): 2017-02-16
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10295/2850
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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