REG Iα Promotes PD-L1 Expression in Esophageal Cancer Cells.

Persistent ID (NDL): info:ndljp/pid/10318142

Material type: 博士論文

Author: 脇田, 晃行ほか

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Publication date: 2015-06-01

Material Format: Digital

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Name of awarding university/degree: 秋田大学,博士（医学）

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Note (General)：: Regenerating gene (REG)Iα is known to contribute to carcinogenesis and to be associated with a poor prognosis in various cancers. Programmed death-1 l...

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Material Type: 博士論文
Title: REG Iα Promotes PD-L1 Expression in Esophageal Cancer Cells.
Author/Editor: 脇田, 晃行
WAKITA, Akiyuki
Author Heading: 脇田, 晃行
WAKITA, Akiyuki
Publication Date: 2015-06-01
Publication Date (W3CDTF): 2015-06-01
Alternative Title: 食道扁平上皮癌細胞において REG Iαは PD-L1 の発現を誘導する
Degree grantor/type: 秋田大学
Date Granted: 2015-03-22
Date Granted (W3CDTF): 2015-03-22
Dissertation Number: 甲第1127号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第1127号
Text Language Code: eng
Subject Heading: PD-L1
REG Iα
esophageal cancer
Target Audience: 一般
Note (General): Regenerating gene (REG)Iα is known to contribute to carcinogenesis and to be associated with a poor prognosis in various cancers. Programmed death-1 ligand(PD-L1) is a negative regulator of T cell activation thought to play an important role in tumor evasion from host immunity.In the present study, we tested the hypothesis that the pro-survival effects of REG Iα in cancer reflect enhanced expression of PD-L1.We found that PD-L1 mRNA expression tended to correspond to REG Iα mRNA levels in esophageal squamous cancer cells, and that REG Iα expression significantly increased expression of both PD-L1 mRNA and protein in TE-5 and TE-9 squamous esophageal cancer cells transfected with REG Iα.In addition, immunohistochemical analysis of squamous cell esophageal cancer specimens revealed that the spatial distribution of PD-L1 expression corresponded to that of REG Iα. These findings suggest that REG Iα may suppress antitumor immunity by inducing PD-L1 expression.
Persistent ID (NDL): info:ndljp/pid/10318142
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
Date Created (W3CDTF): 2017-02-16
Format (IMT): PDF
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Periodical Title (URI): http://hdl.handle.net/10295/2884
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