The clinical course of a gastrointestinal stromal tumor (GIST) diagnosed by endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)

• Material Type: 博士論文
• Title: The clinical course of a gastrointestinal stromal tumor (GIST) diagnosed by endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)
• Author/Editor: 関根, 匡成; SEKINE, Masanari
• Author Heading: 関根, 匡成; SEKINE, Masanari
• Publication, Distribution, etc.: 秋田大学
• Publication Date: 2016-06-01
• Publication Date (W3CDTF): 2016-06-01
• Alternative Title: 超音波内視鏡下穿刺吸引（EUS-FNA）により診断されたGISTの臨床経過
• Degree grantor/type: 秋田大学
• Date Granted: 2016-03-28
• Date Granted (W3CDTF): 2016-03-28
• Dissertation Number: 乙第641号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 乙第641号
• Text Language Code: jpn
• Target Audience: 一般
• Note (General): Objectives:Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumor of the gastrointestinal tract. However, little is known about the clinical presentation of GIST, especially small lesions. The purpose of the present study was to clarify the efficacy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for the diagnosis of GIST and to determine its clinical course.Methods:Pathological and clinical records of GIST extracted from our institutional database between 1996 and 2012 were reviewed. All GIST cases were diagnosed pathologically by surgical specimen or EUS-FNA. To examine the efficacy of EUS-FNA for the diagnosis of GIST, the pathological findings of EUS-FNA were compared with the surgical findings from resected cases. Next, to clarify the clinical presentation of GIST, imaging findings and changes in tumor size over time were evaluated in follow up.Results:Of 84 cases of GIST, 67 were resected surgically after EUS-FNA; tumor size was <20 mm in 19 patients, and ≥20 mm in 48 patients. For the diagnosis of small GIST<20 mm, sensitivity and positive predictive value of EUS-FNA were 81.3% and 100%, respectively. A total of 27 patients with GIST was follow up for more than 1 year. Tumor size increased significantly during follow up. However, generalized linear analysis showed that there was no significant relationship between tumor size and follow up period.Conclusions:The present results showed that even small GIST can be correctly identified by EUS-FNA. Moreover, size of small GIST increased significantly during follow up.
• DOI: info:doi/10.1111/den.12333; https://doi.org/info:doi/10.1111/den.12333
• Persistent ID (NDL): info:ndljp/pid/10318259; https://dl.ndl.go.jp/pid/10318259
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
• Date Created (W3CDTF): 2017-02-16
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://hdl.handle.net/10295/3130
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp