Urinary angiotensinogen level is increased in preterm neonates

Persistent ID (NDL): info:ndljp/pid/10318261

Material type: 博士論文

Author: Suzue, Masashiほか

Publisher: Japanese Society of Nephrology|Springer nature

Publication date: 2014-05-03

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: BackgroundAll components of the renin-angiotensin system (RAS) are abundantly synthesized in the developing kidney, suggesting that the RAS plays an i...

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Material Type: 博士論文
ISSN: 1342-1751
Title: Urinary angiotensinogen level is increased in preterm neonates
Volume: 19 2
Author/Editor: Suzue, Masashi
Urushihara, Maki
Nakagawa, Ryuji
Saijo, Takahiko
Kagami, Shoji
Author Heading: Suzue, Masashi
Urushihara, Maki
Nakagawa, Ryuji
Saijo, Takahiko
Kagami, Shoji
Publication, Distribution, etc.: Japanese Society of Nephrology|Springer nature
Publication Date: 2014-05-03
Publication Date (W3CDTF): 2014-05-03
Alternative Title: 早産児では尿中アンジオテンシノーゲンの排泄量が増加している
Urinary angiotensinogen during renal development in neonates
Periodical title: Clinical and Experimental Nephrology
Degree grantor/type: 徳島大学
Date Granted: 2016-03-23
Date Granted (W3CDTF): 2016-03-23
Dissertation Number: 甲第2901号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第2901号
Text Language Code: eng
Subject Heading: Renin–angiotensin system
Neonates
Renal development
Gestational age
Preterm
Target Audience: 一般
Note (General): BackgroundAll components of the renin-angiotensin system (RAS) are abundantly synthesized in the developing kidney, suggesting that the RAS plays an important role in renal development. To examine this system in human neonates, we measured urinary angiotensinogen levels in preterm and full-term neonates, and examined the relationship between urinary angiotensinogen levels and gestational age.MethodsUrine and plasma samples were collected from 20 preterm and 18 full-term neonates at birth. Angiotensinogen levels were measured using enzyme-linked immunosorbent assay.ResultsPlasma angiotensinogen concentrations were not increased in preterm neonates compared to that in full-term neonates (P = 0.7288). However, the urinary angiotensinogen-to-creatinine ratio was significantly higher in preterm neonates compared to that in full-term neonates (P = 0.0011). Importantly, the urinary angiotensinogen-to-creatinine ratio dropped significantly with increasing gestational age (P = 0.0010), whereas the plasma angiotensinogen concentration was not correlated with gestational age (P = 0.7814).ConclusionsThese results suggest that urinary angiotensinogen levels may indicate the involvement of intrarenal RAS activation in prenatal renal development.
DOI: info:doi/10.1007/s10157-014-0977-y
https://doi.org/info:doi/10.1007/s10157-014-0977-y
Persistent ID (NDL): info:ndljp/pid/10318261
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Collection: 障害者向け資料
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Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
Format (IMT): application/pdf
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/109717
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