Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer

• Material Type: 博士論文
• Title: Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer
• Author/Editor: Takatsuna, Masafumi
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2016-09-20
• Publication Date (W3CDTF): 2016-09-20
• Alternative Title: Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer; 固有筋層における筋線維芽細胞は大腸癌の悪性度に関与する
• Degree grantor/type: 新潟大学
• Date Granted: 2016-09-20
• Date Granted (W3CDTF): 2016-09-20
• Dissertation Number: 甲第4210号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4210号
• Text Language Code: eng
• Subject Heading: colorectal cancer; myofibroblast; muscularis propria; prognosis
• Note (General): Myofibroblasts of colorectal cancer (CRC) have been associated with histopathological factors such as lymph node metastasis, liver metastasis and local recurrence. However, few studies have assessed the association between these malignant traits and the myofibroblast distribution in CRC. We aimed to evaluate the relationship between clinical factors and myofibroblast distribution around CRC invasive lesions. The study included 121 cases of pT3 CRC that were diagnosed at stage II or III. Myofibroblast density of the following three histological layers was measured: the submucosa (SM), muscularis propria (MP) and subserosa (SS). We analyzed the relationship between the clinicopathological factors and myofibroblast density by studying the istopathological features of the three layers. The myofibroblast density of the MP layer was significantly higher in the groups with high-frequency lymphatic and venous invasion than the groups with low-frequency lymphatic (P<0.001) and venous (P<0.01) invasion, respectively. In the positive lymph node metastasis group, the myofibroblast density at the MP layer was significantly higher than that in the negative lymph node metastasis group (P<0.001). The high myofibroblast density group at the MP layer was significantly associated with poor overall survival (P<0.003). Our study indicated that myofibroblasts are a type of cancer-associated fibroblasts and that the myofibroblast distribution contributes to the malignant potential of CRC. Furthermore, we demonstrated that myofibroblasts present at the MP layer play an important role in the malignant potential and poor prognosis of patients with CRC; 学位の種類: 博士（医学）. 報告番号: 甲第4210号. 学位記番号: 新大院博（医）甲第709号. 学位授与年月日: 平成28年9月20日; ONCOLOGY REPORTS; 新大院博（医）甲第709号
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
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• Periodical Title (URI): http://hdl.handle.net/10191/45096
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