Expression of PD-1/LAG-3 and cytokine production by CD4+T cells during infection with Plasmodiumparasites

• Material Type: 博士論文
• ISSN: 0385-5600
• Title: Expression of PD-1/LAG-3 and cytokine production by CD4+T cells during infection with Plasmodiumparasites
• Volume: 60 2
• Author/Editor: Doe, Henrietta Terko
• Author Heading: Doe, Henrietta Terko
• Publication, Distribution, etc.: John Wiley & Sons Australia, Ltd
• Publication Date: 2016-03-18
• Publication Date (W3CDTF): 2016-03-18
• Alternative Title: マラリア原虫感染におけるCD４＋T細胞のPD-1／LAG-3発現とサイトカイン産生の解析
• Periodical title: Microbiology and Immunology
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2016-03-18
• Date Granted (W3CDTF): 2016-03-18
• Dissertation Number: 甲医歯薬第859号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第859号
• Text Language Code: eng
• Subject Heading: malaria; CD4+ T cells; inhibitory receptor; cytokines
• Target Audience: 一般
• Note (General): CD4+ T cells play critical roles in protection against the blood-stage of malaria infection, but their uncontrolled activation can be harmful to the host. We compared the expression of inhibitory receptors on activated CD4+ T cells and their cytokine production using rodent models of Plasmodium parasites, and compared them with those from a bacterial and another protozoan infection. CD4+ T cells from mice infected with P. yoelii 17XL, P yoelii 17XNL, P. chabaudi, P. vinckei, and P. berghei expressed the inhibitory receptors, PD-1 and LAG-3 as early as 6 days after infection, while those from either Listeria monocytogenes or Leishmania major-infected mice did not. In response to T-cell receptor stimulation, CD4+ T cells from mice infected with all the pathogens under study produced high levels of IFN-γ. IL-2 production was reduced in mice infected with Plasmodium species, but not with Listeria or Leishmania. In vitro blockade of the interaction between PD-1 and its ligands resulted in increased IFN-γ production in response to Plasmodium antigens, implying that PD-1 expressed on activated CD4+ T cells actively inhibit T cell immune responses. Studies using Myd88-/-, Trif-/-, and Irf3-/- mice showed that the induction of these CD4+ T cells and their ability to produce cytokines was largely independent of toll-like receptor signaling. These studies suggest that the expression of the inhibitory receptors, PD-1 and LAG-3 on CD4+ T cells and their reduced IL-2 production are common characteristic features of Plasmodium infection.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第859号 学位授与年月日:平成28年3月18日; Author: Henrietta T. Doe, Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Masoud Akbari, Katsuyuki Yui; Citation: Microbiology and Immunology, 60(2), pp.121-131; 2016; Nagasaki University (長崎大学), 博士(医学) (2016-03-18)
• DOI: info:doi/10.1111/1348-0421.12354; https://doi.org/info:doi/10.1111/1348-0421.12354
• Persistent ID (NDL): info:ndljp/pid/10318477; https://dl.ndl.go.jp/pid/10318477
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
• Date Created (W3CDTF): 2020-12-21
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10069/37062; https://nagasaki-u.repo.nii.ac.jp/records/3160
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集