Screening for minimal hepatic encephalopathy in patients with cirrhosis by cirrhosis-related symptoms and a history of overt hepatic encephalopathy

• Material Type: 博士論文
• ISSN: 2049-9434
• Title: Screening for minimal hepatic encephalopathy in patients with cirrhosis by cirrhosis-related symptoms and a history of overt hepatic encephalopathy
• Volume: 5 2
• Author/Editor: 吉村, 映美
• Author Heading: 吉村, 映美
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2017-02-22
• Publication Date (W3CDTF): 2017-02-22
• Alternative Title: 肝硬変に伴う症状と顕性脳症による肝硬変患者におけるミニマル脳症のスクリーニング
• Periodical title: Biomedical Reports
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2017-02-22
• Date Granted (W3CDTF): 2017-02-22
• Dissertation Number: 甲医歯薬第926号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第926号
• Text Language Code: eng
• Subject Heading: overt hepatic encephalopathy history; minimal hepatic encephalopathy; cirrhosis; cirrhosis?related symptom score
• Target Audience: 一般
• Note (General): The diagnosis of minimal hepatic encephalopathy (MHE) is more difficult in comparison to the diagnosis of overt hepatic encephalopathy (OHE), as patients with MHE do not exhibit overt neurological deficits and must be diagnosed using specialized equipment. However, identifying MHE is critical for patients with cirrhosis, and a simple screening test is required. The present study aimed to evaluate the associations between MHE, clinical characteristics and questionnaire items regarding sleep disturbances and cirrhosis?related symptom score (CSS). A total of 91 patients who had cirrhosis without OHE were evaluated using various questionnaires [i.e., CSS, Epworth Sleepiness Scale, the Japanese version of the Pittsburgh Sleep Quality Index (PSQI) and the Japanese 36?item short?form health survey (SF?36)]. MHE was diagnosed using the neuropsychological test. MHE was associated with severe liver damage, which was indicated by liver damage markers and a history of OHE. In addition, MHE was associated with the CSS, PSQI and SF?36 results. The multivariate analyses revealed that a history of OHE was the factor that was the most strongly associated with MHE. Among patients without a history of OHE, MHE was most strongly associated with CSS, although it was also associated with severe liver damage and platelet counts. A prediction score (calculated using a history of OHE and CSS) provided an area under the receiver operating characteristic curve of 0.738 and a sensitivity of 0.671 for identifying MHE. In conclusion, a history of OHE and CSS may be useful for identifying MHE in patients with cirrhosis.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第926号 学位授与年月日:平成29年2月22日; Author: Emi Yoshimura, Tatsuki Ichikawa, Hisamitsu Miyaaki, Naota Taura, Satoshi Miuma, Hidataka Shibata, Takuya Honda, Fuminao Takeshima, Kazuhiko Nakao; Citation: Biomedical Reports, 5(2), pp.193-198; 2016; Nagasaki University (長崎大学), 博士(医学) (2017-02-22)
• DOI: info:doi/10.3892/br.2016.702; https://doi.org/info:doi/10.3892/br.2016.702
• Persistent ID (NDL): info:ndljp/pid/10318478; https://dl.ndl.go.jp/pid/10318478
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
• Date Created (W3CDTF): 2020-12-21
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10069/37061; https://nagasaki-u.repo.nii.ac.jp/records/3874
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集