Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system

• Material Type: 博士論文
• ISSN: 1286-4579
• Title: Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system
• Volume: 18 9
• Author/Editor: 財津, 有未
• Author Heading: 財津, 有未
• Publication, Distribution, etc.: Elsevier Masson
• Publication Date: 2017-03-21
• Publication Date (W3CDTF): 2017-03-21
• Alternative Title: 脂肪滴はヒト肝細胞株におけるPorphyromonas gingivalisのオートファジー・リソソームシステムを介した排除機構に影響する
• Periodical title: Microbes and Infection
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2017-03-21
• Date Granted (W3CDTF): 2017-03-21
• Dissertation Number: 甲医歯薬第916号
• Degree Type: 博士(歯学)
• Conferring No. (Dissertation): 甲医歯薬第916号
• Text Language Code: eng
• Subject Heading: Porphyromonas gingivalis; Non-alcoholic fatty liver disease; Autophagy; Lysosome; HepG2 cells
• Target Audience: 一般
• Note (General): Recent studies have shown that infection with Porphyromonas gingivalis, a major periodontal pathogen, hastens the progression of non-alcoholic fatty liver disease (NAFLD). However, the intracellular fate of P. gingivalis in hepatocytes remains unknown. Here, using oleic-acid-induced HepG2 cells as an in vitro model for NAFLD, we found that lipid droplets increased the existence of P. gingivalis in the cells at an early phase of infection. Confocal microscopic analysis revealed that lipid droplets affected the formation of autolysosomes in infected cells. Thus, lipid droplets affect the elimination of P. gingivalis in HepG2 cells by altering the autophagy-lysosome system.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第916号 学位授与年月日:平成29年3月21日; Author: Yumi Zaitsu, Mayumi Iwatake, Keiko Sato, Takayuki Tsukuba; Citation: Microbes and Infection, 18(9), pp.565-571;2016; Nagasaki University (長崎大学), 博士(歯学) (2017-03-21)
• DOI: info:doi/10.1016/j.micinf.2016.05.004; https://doi.org/info:doi/10.1016/j.micinf.2016.05.004
• Persistent ID (NDL): info:ndljp/pid/10318923; https://dl.ndl.go.jp/pid/10318923
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
• Date Created (W3CDTF): 2020-12-21
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10069/37090; https://nagasaki-u.repo.nii.ac.jp/records/3899
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集