Intermittent administration of parathyroid hormone ameliorates periapical lesions in mice.

• Material Type: 博士論文
• Title: Intermittent administration of parathyroid hormone ameliorates periapical lesions in mice.
• Author/Editor: Otawa, Masato; Tanoue, Ryuichiro; Kido, Hirofumi; Sawa, Yoshihiko; Yamashita, Junro
• Author Heading: Otawa, Masato; Tanoue, Ryuichiro; Kido, Hirofumi; Sawa, Yoshihiko; Yamashita, Junro
• Publication Date: 2017-03-11
• Publication Date (W3CDTF): 2017-03-11
• Alternative Title: Intermittent administration of parathyroid hormone ameliorates periapical lesions in mice.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2017-03-11
• Date Granted (W3CDTF): 2017-03-11
• Dissertation Number: 甲第285号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第285号
• Text Language Code: eng
• Subject Heading: リンフォトキシンアルファ; 好中球; 副甲状腺ホルモン; 根尖性歯周炎; lymphotoxin alpha; neutrophil infiltraion; Animals; Mice, Mutant Strains; Neutrophil Infiltration; Parathyroid Hormone; Periapical Periodontitis
• Target Audience: 一般
• Note (General): Intermittent administration of parathyroid hormone (PTH) promotes oral osseous wound healing and protects against ligature-induced alveolar bone loss. However, its therapeutic value on periapical periodontitis is unknown. The goal of this study was to determine the effect of intermittent PTH administration on the progression of periapical periodontitis.; Seven lymphotoxin alpha-deficient mice received pulp exposures of mandibular first and second molars. Exposed pulp in the right mandible was covered with plaque-contaminated fibrin, whereas exposed pulp in the left mandible was left open. After 4 weeks, the periapical tissues were examined to determine the effect of plaque-contaminated fibrin to induce periapical lesions. Fourteen mice received pulp exposure covered with plaque-contaminated fibrin. PTH (40 μg/kg/d) was administered intermittently to half of the mice for 3 weeks beginning 1 week after pulp exposure. The remaining half received saline injections as the vehicle control. At sacrifice, mandibles and tibiae were harvested and processed for histologic examination. Evaluation of neutrophils and blood vessels was performed after staining with immunofluorescence, and periradicular bone was histomorphometrically analyzed.; The exposed pulp covered with plaque-contaminated fibrin resulted in significantly larger periapical lesions compared with the control. Intermittent PTH administration reduced the size of periapical lesions significantly. Significantly less neutrophil infiltration around the root apex was found in PTH-treated animals compared with the control.; PTH treatment suppressed periapical inflammation by reducing neutrophil infiltration and protected against tissue destruction by periapical periodontitis.
• Persistent ID (NDL): info:ndljp/pid/10319029; https://dl.ndl.go.jp/pid/10319029
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
• Date Created (W3CDTF): 2017-03-29
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/72
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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