Utility of respiratory-gated small-animal PET/CT in the chronologic evaluation of an orthotopic lung cancer transplantation mouse model

• Material Type: 博士論文
• ISSN: 1865-0333
• Title: Utility of respiratory-gated small-animal PET/CT in the chronologic evaluation of an orthotopic lung cancer transplantation mouse model
• Volume: 8 2
• Author/Editor: Otani, Tamaki; Otsuka, Hideki; Kondo, Kazuya; Takizawa, Hiromitsu; Nagata, Motoi; Kishida, Mina; Miyoshi, Hirokazu
• Author Heading: Otani, Tamaki; Otsuka, Hideki; Kondo, Kazuya; Takizawa, Hiromitsu; Nagata, Motoi; Kishida, Mina; Miyoshi, Hirokazu
• Publication, Distribution, etc.: Springer Japan
• Publication Date: 2015-04-29
• Publication Date (W3CDTF): 2015-04-29
• Alternative Title: 肺癌同所移植モデルマウスの経時的評価における小動物用呼吸同期PET/CTの有用性
• Periodical title: Radiological Physics and Technology
• Degree grantor/type: 徳島大学
• Date Granted: 2016-03-23
• Date Granted (W3CDTF): 2016-03-23
• Dissertation Number: 甲第2912号
• Degree Type: 博士（保健学）
• Conferring No. (Dissertation): 甲第2912号
• Text Language Code: eng
• Subject Heading: Respiratory-gated PET/CT; Small animals; Orthotopic lung cancer; 18F-FDG
• Target Audience: 一般
• Note (General): Our aim in this study was to clarify the effects of respiratory-gated PET in the evaluation of lung cancer according to the 18F-FDG uptake in an orthotopic transplantation mouse model. We created such a model, and we performed PET/CT. The mice were divided into two groups according to tumor volume: a small-tumor group (<20 mm3) and a large-tumor group (>20 mm3). We reconstructed the following conditions based on list-mode data: non-gated (3D) images and gated (4D) images, divided based on the respiratory cycle (expiration phase, stable phase, and inspiration phase). We calculated the maximum standardized uptake values (SUVmax) in each phase. We used the % difference [= (4D SUVmax – 3D SUVmax)/3D PET SUVmax × 100 (%)] to evaluate the differences in the 4D SUVmax and 3D SUVmax. The 4D SUVmax values were significantly higher than the 3D SUVmax, regardless of the tumor size. The % difference for the small tumors was greater than that for the large tumors, and it was highest in the stable phase. We conclude that the SUVmax in the stable phase under respiratory-gated PET are the most reliable. The SUVmax observed under non-gated PET are considered to be more frequently underestimated in cases involving small tumors than in those involving large tumors. In the chronologic study evaluating the time course of tumor development, the size of the tumor is small in early stage, and respiratory-gated PET is effective in reducing the underestimation of such tumors caused by respiratory motion.
• DOI: info:doi/10.1007/s12194-015-0316-3; https://doi.org/info:doi/10.1007/s12194-015-0316-3
• Persistent ID (NDL): info:ndljp/pid/10342195; https://dl.ndl.go.jp/pid/10342195
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-05-02T23:17:13+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/109701
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp