Alkalemic conditions result in blood clotting in the circuit soon after initiating cardiopulmonary bypass.

• Material Type: 博士論文
• ISSN: 0912-2664
• Title: Alkalemic conditions result in blood clotting in the circuit soon after initiating cardiopulmonary bypass.
• Volume: 43 4
• Author/Editor: Soyama, Tomonori; Takahashi, Yukihiro; Yoshida, Hideto; Sakoda, Tohru; Niitsuma, Tomokazu; Nishikubo, Toshiya
• Author Heading: Soyama, Tomonori; Takahashi, Yukihiro; Yoshida, Hideto; Sakoda, Tohru; Niitsuma, Tomokazu; Nishikubo, Toshiya
• Publication, Distribution, etc.: 日本体外循環技術医学会
• Publication Date: 2016-12; 43 4
• Publication Date (W3CDTF): 2016-12
• Alternative Title: 体外循環開始後早期にアルカレミア環境で出現する回路内の血液凝集塊形成
• Periodical title: 体外循環技術
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2017-03-15
• Date Granted (W3CDTF): 2017-03-15
• Dissertation Number: 甲第664号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第664号
• Text Language Code: und
• Subject Heading: alkalemic conditions; blood clotting; echinocyte; Donnan equilibrium ratio; albumin
• Target Audience: 一般
• Note (General): type:Thesis; Purpose : This study investigated the relationship between blood clotting in the circuit soon after initiating cardiopulmonary bypass (CPB) and echinocytes that appear with alkalemia, using a recirculation circuit filled with heparinized bovine blood. Methods : Alkalemic conditions in the recirculation circuit were prepared by adding various concentrations of NaHCO3 to the priming fluid. Albumin was also added to confirm its inhibitory effect on blood clotting. Blood pH, hold-up, the pressure gradient, and red blood cell (RBC) reduction rate were monitored. Blood clots were examined microscopically. Results : Although blood pH was elevated under all experimental conditions, clotting in the circuit increased with increased concentrations of HCO3-. Albumin inhibited the clotting under the same alkalemic conditions. Microscopic findings revealed echinocytes in the blood clots. Conclusions : The shape of echinocytes was transformed by a reduction in the Donnan equilibrium ratio because of changes in pH inside and outside the RBC membrane. Blood clotting in the circuit soon after initiating CPB may be caused by echinocytes that appear under alkalemic conditions. This was inhibited by albumin, suggesting that the addition of albumin to the priming fluid may prevent such clotting in the circuit after initiating CPB.; 博士（医学）・甲第664号・平成29年3月15日; Copyright © 2016 Japanese Journal of Extra-Corporeal Technology（日本体外循環技術医学会）; This is a non-final version of an article published in final form in "http://doi.org/10.7130/jject.43.339"; identifier:体外循環技術 43巻4号 p.339-345 (2016.12); identifier:09122664; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3317; identifier:体外循環技術, 43(4): 339-345
• DOI: info:doi/10.7130/jject.43.339; https://doi.org/info:doi/10.7130/jject.43.339
• Persistent ID (NDL): info:ndljp/pid/10342511; https://dl.ndl.go.jp/pid/10342511
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-05-02T23:17:13+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3317
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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