Alternative Title子宮頸癌根治的放射線治療期間中の子宮移動の予測因子について
Periodical titleJournal of Radiation Research
Note (General)To determine the predictive factors affecting uterine movement during radiotherapy (RT), we quantified interfraction<br/>uterine movement using computed tomography (CT) and cone-beam CT (CBCT). A total of 38 patients<br/>who underwent definitive RT for cervical cancer were retrospectively analyzed. We compared pre-RT planning CT<br/>(n = 38) and intratreatment CBCT (n = 315), measuring cervical and corporal movement in each direction. Correlations between uterine movement and volume changes of the bladder and rectum on all CBCT scans were<br/>analyzed using Spearman rank correlation analysis. Relationships between the mean uterine movement and patient<br/>factors were analyzed using the Mann–Whitney test. The mean corpus movement was: superior margin (cranio–<br/>caudal direction), 7.6 ± 5.9 mm; anterior margin (anteroposterior direction), 8.3 ± 6.3 mm; left margin (lateral direction),<br/>3.3 ± 2.9mm; and right margin (lateral direction), 3.0 ± 2.3 mm. Generally, the mean values for cervical<br/>movement were smaller than those for the corpus. There was a significant, weak correlation between changes in<br/>bladder volume and the movement of the superior margin of the corpus (ρ = 0.364, P < 0.001). There was a significant<br/>difference in movement of the superior margin of the corpus between the subgroups with and without a<br/>history of previous pelvic surgery (P = 0.007). In conclusion, change in bladder volume and a history of previous<br/>surgery were significantly related to intrafractional corpus movement; however, our observations suggest that the<br/>accurate prediction of uterine movement remains challenging.
学位論文
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2017-07-03T04:10:06+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション