Inhibition of glutaminolysis inhibits cell growth via down-regulating mTORC1 signaling in lung squamous cell carcinoma.

• Material Type: 博士論文
• Title: Inhibition of glutaminolysis inhibits cell growth via down-regulating mTORC1 signaling in lung squamous cell carcinoma.
• Author/Editor: Ye, Xu Lu
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2017-03-23
• Publication Date (W3CDTF): 2017-03-23
• Alternative Title: Inhibition of glutaminolysis inhibits cell growth via down-regulating mTORC1 signaling in lung squamous cell carcinoma.; 肺扁平上皮癌におけるmTORC1シグナル活性低下を介するグルタミン代謝阻害による細胞増殖抑制
• Degree grantor/type: 新潟大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第4247号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4247号
• Text Language Code: eng
• Subject Heading: Lung squamous cell carcinoma; molecular targeted therapy; glutaminolysis; glutaminase; BPTES; mTORC1
• Note (General): Background/Aim: Inhibition of glutaminolysis has been reported as a promising therapeutic strategy to target several solid carcinomas. We aimed to investigate the effects of glutaminolysis on cell proliferation in lung squamous cell carcinoma cell lines and to explore the potential of targeting glutaminolysis as an anticancer strategy. Materials and Methods: Glutamine (Gln) dependence was assessed in six lung squamous cell carcinoma cell lines. Cell proliferation, mammalian target of rapamycin complex 1 (mTORC1) activity and the induction of autophagy were assessed after inhibition of glutaminolysis via Gln depletion or glutaminase (GLS) inhibition. Results: Five of six lung squamous cell carcinoma cell lines exhibited glutamine-dependence. The extent of dependence was correlated with the mRNA levels of GLS1/GLS2. Inhibition of glutaminolysis inhibited cell proliferation by down-regulating of mTORC1 signaling and inducing autophagy in Gln-dependent lung squamous cell carcinoma cell lines. Conclusion: Targeting glutaminolysis may represent a potential therapeutic strategy for the treatment of Gln-dependent lung squamous cell carcinomas.; 学位の種類: 博士（医学）. 報告番号: 甲第4247号. 学位記番号: 新大院博（医）甲第725号. 学位授与年月日: 平成29年3月23日; Anticancer Research 36(11) 6021-6029(2016); 新大院博（医）甲第725号; 元資料の権利情報 : Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
• DOI: info:doi/10.21873/anticanres.11191; https://doi.org/info:doi/10.21873/anticanres.11191
• Persistent ID (NDL): info:ndljp/pid/10371258; https://dl.ndl.go.jp/pid/10371258
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-07-03T04:10:06+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/47578
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp