Donor killer immunoglobulin-like receptor haplotype B/x induces severe acute graft-versus-host disease in the presence of HLA mismatch in T-cell replete hematopoietic cell transplantation.

• Material Type: 博士論文
• Title: Donor killer immunoglobulin-like receptor haplotype B/x induces severe acute graft-versus-host disease in the presence of HLA mismatch in T-cell replete hematopoietic cell transplantation.
• Author/Editor: Hosokai, Ryosuke
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2017-03-23
• Publication Date (W3CDTF): 2017-03-23
• Alternative Title: Donor killer immunoglobulin-like receptor haplotype B/x induces severe acute graft-versus-host disease in the presence of HLA mismatch in T-cell replete hematopoietic cell transplantation.; ドナーKIRハプロタイプB/xはHLA不一致T細胞非除去造血幹細胞移植において重症急性GVHDを引き起こす
• Degree grantor/type: 新潟大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第4261号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4261号
• Text Language Code: eng
• Subject Heading: Killer immunoglobulin-like receptor haplotype; Acute graft-versus-host disease; Allogeneic hematopoietic cell transplantation
• Note (General): Natural killer cells have been identified as a mediator of alloimmune reactions in allogeneic hematopoietic stem cell transplantation (HSCT). Killer immunoglobulin-like receptors (KIRs) are an important determinant of natural killer cell function. The relationship between KIR genotypes/haplotypes and clinical outcomes of allogeneic HSCT is complex and inconsistent among several reports. We assessed the clinical impact of KIR haplotype on T cell–replete allogeneic HSCTs performed in a single Japanese center for hematological malignancies (n = 106). A comparison of 2 groups, donor haplotypes A/A and B/x, revealed no significant differences in overall survival, relapse, and nonrelapse mortality. However, grade III to IV acute graft-versus-host disease (GVHD) occurred significantly more frequently in the KIR haplotype B/x group (A/A versus B/x: 4.9% versus 20.0%; P = .02). This was even more evident when HLA mismatch was present. The highest incidences of grade II to IV and grade III to IV acute GVHD were observed in patients who received allografts from HLA-mismatched donors with KIR haplotype B/x. These data highlight the importance of KIR genotyping in donor matching, especially when HLA mismatch allogeneic grafting is planned.; 学位の種類: 博士（医学）. 報告番号: 甲第4261号. 学位記番号: 新大院博（医）甲第739号. 学位授与年月日: 平成29年3月23日; Biology of Blood and Marrow Transplantation 23(4)606-611,2017; 新大院博（医）甲第739号; 元資料の権利情報 : © 2017 Published by Elsevier Inc. on behalf of the American Society for Blood and Marrow Transplantation.
• DOI: info:doi/10.1016/j.bbmt.2016.12.638; https://doi.org/info:doi/10.1016/j.bbmt.2016.12.638
• Persistent ID (NDL): info:ndljp/pid/10371267; https://dl.ndl.go.jp/pid/10371267
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-07-03T04:10:06+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://hdl.handle.net/10191/47592
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp