Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors.

• Material Type: 博士論文
• Title: Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors.
• Author/Editor: Sato, Ko
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2017-03-23
• Publication Date (W3CDTF): 2017-03-23
• Alternative Title: Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors.; 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析
• Degree grantor/type: 新潟大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第4268号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4268号
• Text Language Code: eng
• Subject Heading: Cisplatin; Nephrotoxicity; Chronic kidney disease; Acute kidney injury
• Note (General): Background : Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who received cisplatin combination chemotherapy. Recent evidence has demonstrated that patients with chronic kidney disease (CKD) have an increased risk of developing acute kidney injury (AKI). The present study was conducted to evaluate the prevalence of CKD risk factors in patients who received cisplatin and to assess the correlation between CKD risk factors and cisplatin-induced AKI.\ Methods : We retrospectively analyzed 84 patients treated with cisplatin combination chemotherapy for thoracic malignancies. AKI was defined as a decrease in the estimated glomerular filtration rate (eGFR) > 25 % from base line, an increase in the serum creatinine (sCre) level of > 0.3 mg/dl or ≥ 1.5 times the baseline level.\ Results : Eighty of the 84 patients (95.2 %) had at least one risk factor for CKD. All enrolled patients received cisplatin with hydration, magnesium supplementation and mannitol. Cisplatin-induced AKI was observed in 18 patients (21.4 %). Univariate analysis revealed that cardiac disease and use of non-steroidal anti-inflammatory drugs (NSAIDs) were associated with cisplatin-induced nephrotoxicity (odds ratios [OR] 6 and 3.56, 95 % confidence intervals [CI] 1.21–29.87 and 1.11–11.39, p = 0.04 and p = 0.04, respectively). Multivariate analysis revealed that cisplatin nephrotoxicity occurred significantly more often in patients with both risk factors (OR 13.64, 95 % CI 1.11–326.83, p = 0.04). Patients with more risk factors for CKD tended to have a greater risk of developing cisplatin-induced AKI.\ Conclusions : We should consider avoiding administration of cisplatin to patients with CKD risk factors, particularly cardiac disease and NSAID use.; 学位の種類: 博士（医学）. 報告番号: 甲第4268号. 学位記番号: 新大院博（医）甲第746号. 学位授与年月日: 平成29年3月23日; BMC Cancer. 2016; 16: 222; 新大院博（医）甲第746号
• DOI: info:doi/10.1186/s12885-016-2271-8; https://doi.org/info:doi/10.1186/s12885-016-2271-8
• Persistent ID (NDL): info:ndljp/pid/10371272; https://dl.ndl.go.jp/pid/10371272
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-07-03T04:10:06+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/47613
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp