ABCG2 expression in colorectal adenocarcinomas may predict resistance to irinotecan.

• Material Type: 博士論文
• ISSN: 1792-1074
• Title: ABCG2 expression in colorectal adenocarcinomas may predict resistance to irinotecan.
• Volume: 12 4
• Author/Editor: TUY, Hoang Dinh
• Author Heading: TUY, Hoang Dinh
• Publication, Distribution, etc.: Spandidos publications
• Publication Date: 2016-08-03
• Publication Date (W3CDTF): 2016-08-03
• Periodical title: Oncology letters
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2015-09-09
• Date Granted (W3CDTF): 2015-09-09
• Dissertation Number: 甲第738号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第738号
• Text Language Code: eng
• Subject Heading: colorectal adenocarcinoma; ABCG2; irinotecan; drug resistance
• Target Audience: 一般
• Note (General): Irinotecan is a key drug for patients with advanced and recurrent colorectal carcinoma. However, the efficacy of irinotecan is not sufficient; partly, as there is no useful marker to predict chemosensitivity to the drug. The aim of the present study was to evaluate whether the expression levels of adenosine triphosphate-binding cassette sub-family G (WHITE) member 2 (Junior blood group) (ABCG2) in primary colorectal tumors predict chemoresistance to irinotecan. Using the resected primary tumor specimens of 189 patients with colorectal cancer, the association between the immunohistochemical expression of ABCG2 protein and the results of the collagen gel droplet embedded culture drug sensitivity test, performed to evaluate the chemosensitivity to SN-38 (an active metabolite of irinotecan), was investigated. Among the 189 patients, 17 received irinotecan-based chemotherapy, and their responses and progression-free survival (PFS) were analyzed. The tumors of patients with increased ABCG2 expression accounted for 60% of the tumors examined, and were significantly more resistant to SN-38, compared with patients with low ABCG2 expression (P<0.001). In a multivariate logistic regression analysis, increased expression of ABCG2 protein was an independent and significant predictor of resistance to SN-38, increasing the risk of resistance by 12-fold. Increased expression of ABCG2 and a low sensitivity to SN-38 was significantly associated with resistance to irinotecan-based chemotherapy (P=0.01 and 0.028, respectively). The median PFS of patients with increased expression of ABCG2 was significantly shorter, compared with patients with low expression levels of ABCG2 (104 vs. 242 days; P=0.047). The increased immunohistochemical expression of ABCG2 in primary tumors may be a useful predictive biomarker of resistance to irinotecan-based chemotherapy for patients with recurrent or metastatic colorectal cancer.; Thesis or Dissertation; 平成27年度; 10.3892/ol.2016.4937; 出版社サイト
• DOI: info:doi/10.3892/ol.2016.4937; https://doi.org/info:doi/10.3892/ol.2016.4937
• Persistent ID (NDL): info:ndljp/pid/10371925; https://dl.ndl.go.jp/pid/10371925
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-07-03T04:10:06+09:00
• Date Created (W3CDTF): 2017-05-01
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): http://dx.doi.org/10.3892/ol.2016.4937
• Periodical Title (URI): http://hdl.handle.net/10422/00012255; https://shiga-med.repo.nii.ac.jp/records/3089
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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