Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal.

• Material Type: 博士論文
• ISSN: 2072-6643
• Title: Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal.
• Volume: 7
• Author/Editor: NAGAYAMA, Kohji
• Author Heading: NAGAYAMA, Kohji
• Publication, Distribution, etc.: Molecular Diversity Preservation International
• Publication Date: 2015-09-21
• Publication Date (W3CDTF): 2015-09-21
• Periodical title: Nutrients
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2016-03-10
• Date Granted (W3CDTF): 2016-03-10
• Dissertation Number: 甲第746号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第746号
• Text Language Code: eng
• Subject Heading: monocyte chemotactic protein 1; 4-hydroxy hexenal; docosahexaenoic acid; eicosapentaenoic acid
• Target Audience: 一般
• Note (General): N-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have protective effects against atherosclerosis. Monocyte chemotactic protein (MCP)-1 is a major inflammatory mediator in the progression of atherosclerosis. However, little is known about the regulation of MCP-1 by DHA and EPA in vessels and vascular smooth muscle cells (VSMCs). In this study, we compared the effect of DHA and EPA on the expression of Mcp-1 in rat arterial strips and rat VSMCs. DHA, but not EPA, suppressed Mcp-1 expression in arterial strips. Furthermore, DHA generated 4-hydroxy hexenal (4-HHE), an end product of n-3 polyunsaturated fatty acids (PUFAs), in arterial strips as measured by liquid chromatography-tandem mass spectrometry. In addition, 4-HHE treatment suppressed Mcp-1 expression in arterial strips, suggesting 4-HHE derived from DHA may be involved in the mechanism of this phenomenon. In contrast, Mcp-1 expression was stimulated by DHA, EPA and 4-HHE through p38 kinase and the Keap1-Nuclear factor erythroid-derived 2-like 2 (Nrf2) pathway in VSMCs. In conclusion, there is a dual effect of n-3 PUFAs on the regulation of Mcp-1 expression. Further study is necessary to elucidate the pathological role of this phenomenon.; Thesis or Dissertation; 平成27年度; 10.3390/nu7095381
• DOI: info:doi/10.3390/nu7095381; https://doi.org/info:doi/10.3390/nu7095381
• Persistent ID (NDL): info:ndljp/pid/10371926; https://dl.ndl.go.jp/pid/10371926
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-07-03T04:10:06+09:00
• Date Created (W3CDTF): 2017-05-09
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/00012275; https://shiga-med.repo.nii.ac.jp/records/3108
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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