Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.
• Volume: 6
• Author/Editor: TAKAGI, Ayano
• Author Heading: TAKAGI, Ayano
• Publication, Distribution, etc.: Nature Publishing Group
• Publication Date: 2016-01-06
• Publication Date (W3CDTF): 2016-01-06
• Periodical title: Scientific Reports
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2016-03-10
• Date Granted (W3CDTF): 2016-03-10
• Dissertation Number: 甲第747号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第747号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Autophagy is an intracellular degradation system activated, across species, by starvation. Although accumulating evidence has shown that mammalian autophagy is involved in pathogenesis of several modern diseases, its physiological role to combat starvation has not been fully clarified. In this study, we analysed starvation-induced gluconeogenesis and ketogenesis in mouse strains lacking autophagy in liver, skeletal muscle or kidney. Autophagy-deficiency in any tissue had no effect on gluconeogenesis during starvation. Though skeletal muscle- and kidney-specific autophagy-deficiency did not alter starvation-induced increases in blood ketone levels, liver-specific autophagy-deficiency significantly attenuated this effect. Interestingly, renal as well as hepatic expression of HMG-CoA synthase 2 increased with prolonged starvation. Furthermore, during starvation, mice lacking autophagy both in liver and kidney showed even lower blood ketone levels and physical activity than mice lacking autophagy only in liver. Starvation induced massive lipid droplet formation in extra-adipose tissues including liver and kidney, which was essential for ketogenesis. Moreover, this process was impaired in the autophagy-deficient liver and kidney. These findings demonstrate that hepatic and renal autophagy are essential for starvation-induced lipid droplet formation and subsequent ketogenesis and, ultimately, for maintaining systemic energy homeostasis. Our findings provide novel biological insights into adaptive mechanisms to combat starvation in mammals.; Thesis or Dissertation; 平成27年度; 10.1038/srep18944
• DOI: info:doi/10.1038/srep18944; https://doi.org/info:doi/10.1038/srep18944
• Persistent ID (NDL): info:ndljp/pid/10371927; https://dl.ndl.go.jp/pid/10371927
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-07-03T04:10:06+09:00
• Date Created (W3CDTF): 2017-05-09
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/00012280; https://shiga-med.repo.nii.ac.jp/records/3116
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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