Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor. 6

• Material Type: 博士論文
• ISSN: 1932-6203
• Title: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor.
• Volume: 10 6
• Author/Editor: YOSHIMURA, Yayoi
• Author Heading: YOSHIMURA, Yayoi
• Publication, Distribution, etc.: Public Library of Science
• Publication Date: 2015-06-03
• Publication Date (W3CDTF): 2015-06-03
• Periodical title: PLoS ONE
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2016-03-10
• Date Granted (W3CDTF): 2016-03-10
• Dissertation Number: 乙第424号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第424号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Glioblastoma multiforme (GBM) is associated with high mortality due to infiltrative growth and recurrence. Median survival of the patients is less than 15 months, increasing requirements for new therapies. We found that both arsenic trioxide and 10058F4, an inhibitor of Myc, induced differentiation of cancer stem-like cells (CSC) of GBM and that arsenic trioxide drastically enhanced the anti-proliferative effect of 10058F4 but not apoptotic effects. EGFR-driven genetically engineered GBM mouse model showed that this cooperative effect is higher in EGFRvIII-expressing INK4a/Arf-/- neural stem cells (NSCs) than in control wild type NSCs. In addition, treatment of GBM CSC xenografts with arsenic trioxide and 10058F4 resulted in significant decrease in tumor growth and increased differentiation with concomitant decrease of proneural and mesenchymal GBM CSCs in vivo. Our study was the first to evaluate arsenic trioxide and 10058F4 interaction in GBM CSC differentiation and to assess new opportunities for arsenic trioxide and 10058F4 combination as a promising approach for future differentiation therapy of GBM.; Thesis or Dissertation; 平成27年度; 10.1371/journal.pone.0128288
• DOI: info:doi/10.1371/journal.pone.0128288; https://doi.org/info:doi/10.1371/journal.pone.0128288
• Persistent ID (NDL): info:ndljp/pid/10371931; https://dl.ndl.go.jp/pid/10371931
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-07-03T04:10:06+09:00
• Date Created (W3CDTF): 2017-05-11
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/00012288; https://shiga-med.repo.nii.ac.jp/records/3131
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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