Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model.

• Material Type: 博士論文
• ISSN: 1341-1357
• Title: Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model.
• Volume: 65 4
• Author/Editor: 越沼, 伸也
• Author Heading: 越沼, 伸也
• Publication, Distribution, etc.: 日本実験動物学会
• Publication Date: 2016-07-05
• Publication Date (W3CDTF): 2016-07-05
• Periodical title: Experimental Animals
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2016-09-14
• Date Granted (W3CDTF): 2016-09-14
• Dissertation Number: 乙第426号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第426号
• Text Language Code: eng
• Subject Heading: dressing material; osteoblast; periosteum; wound healing
• Target Audience: 一般
• Note (General): Oral surgical procedures occasionally require removal of the periosteum due to lesions, and these raw bone surfaces are prone not only to infection but also to scar formation during secondary healing. The objective of this study was to identify successful methods for reconstruction using periosteal defect dressings. We created 1-cm2 defects in the skin and cranial periosteum of 10-week-old male Wistar rats under isoflurane anesthesia. The animals were assigned to three defect treatment groups: (1) polyglycolic acid sheets with fibrin glue dressing (PGA-FG), (2) Spongel® gelatin sponge dressing (GS), and (3) open wound (control). Postoperative wound healing was histologically evaluated at 2, 4, and 6 weeks. The moist conditions maintained by the GS and PGA-FG treatments protected the bone surface from the destructive effects of drying and infection. Complete wound healing was observed in the GS group but not for all animals in the PGA-FG and control groups. Histologically, osteoblast proliferation on bone surfaces and complete epithelialization with adnexa were observed in the GS group at 6 weeks after surgery. In contrast, PGA sheets that had not been absorbed inhibited osteoblast proliferation and delayed wound healing in the PGA-FG group. Wound surface dressings maintain a moist environment that promotes wound healing, but PGA materials may not be suitable for cases involving exposed periosteum or bone surfaces due to the observed scar formation and foreign-body reaction.; Thesis or Dissertation; 平成28年度; 10.1538/expanim.16-0031; J-STAGE
• DOI: info:doi/10.1538/expanim.16-0031; https://doi.org/info:doi/10.1538/expanim.16-0031
• Persistent ID (NDL): info:ndljp/pid/10371932; https://dl.ndl.go.jp/pid/10371932
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-07-03T04:10:06+09:00
• Date Created (W3CDTF): 2017-05-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): http://dx.doi.org/10.1538/expanim.16-0031
• Periodical Title (URI): http://hdl.handle.net/10422/00012289; https://shiga-med.repo.nii.ac.jp/records/3133
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-07-18 再収集