Suppressed Production of Soluble Fms-Like Tyrosine Kinase-1 Contributes to Myocardial Remodeling and Heart Failure. 3

• Material Type: 博士論文
• Title: Suppressed Production of Soluble Fms-Like Tyrosine Kinase-1 Contributes to Myocardial Remodeling and Heart Failure.
• Volume: 68 3
• Author/Editor: Seno, Ayako; Takeda, Yukiji; Matsui, Masaru; Okuda, Aya; Nakano, Tomoya; Nakada, Yasuki; Kumazawa, Takuya; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Somekawa, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Kawakami, Rika; Okura, Hiroyuki; Uemura, Shiro; Saito, Yoshihiko
• Author Heading: Seno, Ayako; Takeda, Yukiji; Matsui, Masaru; Okuda, Aya; Nakano, Tomoya; Nakada, Yasuki; Kumazawa, Takuya; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Somekawa, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Kawakami, Rika; Okura, Hiroyuki; Uemura, Shiro; Saito, Yoshihiko
• Publication, Distribution, etc.: American Heart Association / Lippincott, Williams & Wilkins
• Publication Date: 2016-09; 68 3
• Publication Date (W3CDTF): 2016-09
• Alternative Title: 可溶性Flt-1産生低下は、心筋リモデリングおよび心不全増悪に寄与する
• Periodical title: Hypertension
• Pages: 678-687
• ISSN (Periodical Title): 0194911X
• Degree Grantor: 奈良県立医科大学
• Date Granted: 2016-11-24
• Date Granted (W3CDTF): 2016-11-24
• Dissertation Number: 乙第1384号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1384号
• Text Language Code: eng
• Subject Heading: chronic kidney disease; heart failure; hypertrophy/remodeling; monocyte chemoattractant protein-1; placental growth factor
• Target Audience: 一般
• Note (General): type:Thesis; Soluble fms-like tyrosine kinase-1 (sFlt-1), an endogenous inhibitor of vascular endothelial growth factor and placental growth factor, is involved in the pathogenesis of cardiovascular disease. However, the significance of sFlt-1 in heart failure has not been fully elucidated. We found that sFlt-1 is decreased in renal failure and serves as a key molecule in atherosclerosis. In this study, we aimed to investigate the role of the decreased sFlt-1 production in heart failure, using sFlt-1 knockout mice. sFlt-1 knockout mice and wild-type mice were subjected to transverse aortic constriction and evaluated after 7 days. The sFlt-1 knockout mice had significantly higher mortality (52% versus 15%; P=0.0002) attributable to heart failure and showed greater cardiac hypertrophy (heart weight to body weight ratio, 8.95±0.45 mg/g in sFlt-1 knockout mice versus 6.60±0.32 mg/g in wild-type mice; P<0.0001) and cardiac dysfunction, which was accompanied by a significant increase in macrophage infiltration and cardiac fibrosis, than wild-type mice after transverse aortic constriction. An anti–placental growth factor–neutralizing antibody prevented pressure overload–induced cardiac hypertrophy, fibrosis, and cardiac dysfunction. Moreover, monocyte chemoattractant protein-1 expression was significantly increased in the hypertrophied hearts of sFlt-1 knockout mice compared with wild-type mice. Monocyte chemoattractant protein-1 inhibition with neutralizing antibody ameliorated maladaptive cardiac remodeling in sFlt-1 knockout mice after transverse aortic constriction. In conclusion, decreased sFlt-1 production plays a key role in the aggravation of cardiac hypertrophy and heart failure through upregulation of monocyte chemoattractant protein-1 expression in pressure-overloaded heart.; 博士（医学）・乙第1384号・平成28年11月24日; © 2016 American Heart Association, Inc.; The definitive version is available at " https://doi.org/10.1161/HYPERTENSIONAHA.116.07371 "; identifier:Hypertension Vol.68 No.3 p.678-687 (2016 Sep); identifier:0194911X; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3289; identifier:Hypertension, 68(3): 678-687
• Persistent ID (NDL): info:ndljp/pid/10402666; https://dl.ndl.go.jp/pid/10402666
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-08-02T04:31:34+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): https://doi.org/10.1161/HYPERTENSIONAHA.116.07371
• Periodical Title (URI): http://hdl.handle.net/10564/3289
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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