Alternative Title白内障手術既往のある高齢者は視力と独立して高い認知機能を維持する : 平城京コホート研究横断解析
Note (General)type:Thesis
Cataract surgery improves visual acuity and drastically increases the capacity for light reception to the retina. Although previous studies suggested that both light exposure and visual acuity were associated with cognitive function, the relationships between cataract surgery, visual acuity, and cognitive function have not been evaluated in large populations. In this cross-sectional study, we measured cognitive function using the Mini-Mental State Examination and best-corrected visual acuity in pseudophakic (previous cataract surgery) and phakic (no previous cataract surgery) elderly individuals. Of 945 participants (mean age 71.7 years), 166 (17.6%) had pseudophakia and 317 (33.5%) had impaired cognitive function (score ≤26). The pseudophakic group showed significantly better visual acuity than the phakic group (p = 0.003) and lower age-adjusted odds ratio (ORs) for cognitive impairment (OR 0.66; p = 0.038). Consistently, in multivariate logistic regression models, after adjusting for confounding factors, including visual acuity and socioeconomic status, ORs for cognitive impairment were significantly lower in the pseudophakic group than in the phakic group (OR 0.64; 95% confidence interval 0.43-0.96; p = 0.031). This association remained significant in sensitivity analysis, excluding participants with low cognitive score ≤23 (n = 36). In conclusion, in a general elderly population, prevalence of cognitive impairment was significantly lower in pseudophakic individuals independently of visual acuity. The association was also independent of several major causes of cognitive impairment such as aging, gender, obesity, socioeconomic status, hypertension, diabetes, sleep disturbances, depressive symptoms, and physical inactivity.
博士(医学)・甲第666号・平成29年3月15日
© Mary Ann Liebert, Inc.
This is a non-final version of an article published in final form in "http://dx.doi.org/10.1089/rej.2015.1718"
identifier:Rejuvenation research Vol.19 No.3 p.239-243 (2016 Jun)
identifier:15491684
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3319
identifier:Rejuvenation research, 19(3): 239-243
DOIinfo:doi/10.1089/rej.2015.1718
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2017-08-02T04:31:34+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション