Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice

• Material Type: 博士論文
• ISSN: 1449-1907
• Title: Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice
• Volume: 13 4
• Author/Editor: Mimura, Hiroaki; Takaya, Tatsuo; Matsuda, Saeka; Nakano, Keisuke; Muraoka, Rina; Tomida, Mihoko; Okafuji, Norimasa; Fujii, Takeo; Kawakami, Toshiyuki; 三村, 泰亮
• Publication Date: 2016-02-20
• Publication Date (W3CDTF): 2016-02-20
• Alternative Title: マウス歯根膜における咬合過重負荷時のHSP47 の機能的役割
• Periodical title: International Journal of Medical Sciences
• Degree grantor/type: 松本歯科大学
• Date Granted: 2017-02-09
• Date Granted (W3CDTF): 2017-02-09
• Dissertation Number: 甲第203号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第203号
• Text Language Code: eng
• Subject Heading: Occlusal trauma; Periodontal ligament; Immunohistochemistry; HSP47; Mouse
• Note (General): We carried out an experiment to induce traumatic occlusion in mice periodontal tissue and analyzed the expression of HSP47. Continuous traumatic occlusion resulted to damage and remodeling of periodontal ligament as well as increase in osteoclasts and bone resorption. Four days after traumatic occlusion, osteoclasts did not increase but Howship’s lacunae became enlarged. That is, the persistent occlusal overload can destroy collagen fibers in the periodontal ligament. This was evident by the increased in HSP47 expression with the occlusal overload. HSP47 is maintained in fibroblasts for repair of damaged collagen fibers. On the other hand, osteoclasts continue to increase although the load was released. The osteoclasts that appeared on the alveolar bone surface were likely due to sustained activity. The increase in osteoclasts was estimated to occur after load application at day 4. HSP47 continued to increase until day 6 in experiment 2 but then reduced at day 10. Therefore, HSP47 appears after a period of certain activities to repair damaged collagen fibers, and the activity was returned to a state of equilibrium at day 30 with significantly diminished expression. Thus, the results suggest that HSP47 is actively involved in homeostasis of periodontal tissue subjected to occlusal overload.; 2016; identifier:甲第203号; PubMed番号 : 27076780; 元資料の権利情報 : Copyright: 2016 © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.; 元資料の権利情報 : CC BY-NC; 開始ページ : 248; 終了ページ : 254
• DOI: info:doi/10.7150/ijms.14129; https://doi.org/info:doi/10.7150/ijms.14129
• Persistent ID (NDL): info:ndljp/pid/10402831; https://dl.ndl.go.jp/pid/10402831
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-08-02T04:31:34+09:00
• Date Created (W3CDTF): 2017-04-27
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
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• Availability of remote photoduplication service: 可
• Original Material (URI): 雑誌掲載論文(電子版); http://www.medsci.org/v13p0248.htm
• Periodical Title (URI): http://id.nii.ac.jp/1070/00002656/
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp