Activation of FGF2-FGFR Signaling in the Castrated Mouse Prostate Stimulates the Proliferation of Basal Epithelial Cells.

• Material Type: 博士論文
• Title: Activation of FGF2-FGFR Signaling in the Castrated Mouse Prostate Stimulates the Proliferation of Basal Epithelial Cells.
• Author/Editor: Kato, Manabu
• Author Heading: Kato, Manabu
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2016-03-25
• Publication Date (W3CDTF): 2016-03-25
• Degree grantor/type: 三重大学
• Date Granted: 2016-03-25
• Date Granted (W3CDTF): 2016-03-25
• Dissertation Number: 甲医学第1766号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1766号
• Text Language Code: eng
• Alias of Author: カトウ, マナブ; 加藤, 学
• Subject Heading: basal epithelial cells; castration; fibroblast growth factor 2; fibroblast growth factor receptor; growth factor; organ culture; prostate
• Target Audience: 一般
• Note (General): application/pdf; The prostate gland is unique in that it undergoes rapid regression following castration but regenerates completely once androgens are replaced. Residual ductal components play an important role in the regeneration of a fully functional prostate. In this study, to examine how androgen status affects prostate structure and components, we conducted histopathological studies of the involuted and regenerated mouse dorsolateral prostate (DLP). In the castrated mouse DLP, the number of luminal epithelial cells decreased in a time-dependent manner. On Day 14 postandrogen replacement, the number of luminal epithelial cells was completely restored to the baseline level. In contrast, the number of basal epithelial cells gradually increased in the castrated mouse prostate. The Ki67-labeling index of prostate basal epithelial cells was significantly increased after castration. The number of basal epithelial cells decreased to baseline after androgen replacement. After castration, mRNA expression levels of specific growth factors, such as Fgf2, Fgf7, Hgf, Tgfa, and Tgfb, were relatively abundant in whole mouse DLPs. In organ culture experiments, basal epithelial proliferation was recapitulated in the absence of dihydrotestosterone (DHT). The proliferation of basal epithelial cells in the absence of DHT was suppressed by treatment with an FGF receptor inhibitor (PD173074). Moreover, FGF2 treatment directly stimulated the proliferation of basal epithelial cells. Taken together, these data indicated that the FGF2-FGF receptor signal cascade in the prostate gland may be one of the pathways stimulating the proliferation of basal epithelial cells in the absence of androgens. basal epithelial cells, castration, fibroblast growth factor 2, fibroblast growth factor receptor, growth factor, organ culture, prostate; 本文 / Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine; 10p; https://doi.org/10.1095/biolreprod.112.107516
• DOI: info:doi/10.1095/biolreprod.112.107516; https://doi.org/info:doi/10.1095/biolreprod.112.107516
• Persistent ID (NDL): info:ndljp/pid/10402942; https://dl.ndl.go.jp/pid/10402942
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-08-02T04:31:34+09:00
• Date Created (W3CDTF): 2017-07-04
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): https://doi.org/10.1095/biolreprod.112.107516
• Periodical Title (URI): http://hdl.handle.net/10076/00016972; https://mie-u.repo.nii.ac.jp/records/11316
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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