Human equilibrative nucleoside transporter-1 (hENT1) expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy

• Material Type: 博士論文
• Title: Human equilibrative nucleoside transporter-1 (hENT1) expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy
• Author/Editor: Yamada, Reiko
• Author Heading: Yamada, Reiko
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2016-03-25
• Publication Date (W3CDTF): 2016-03-25
• Degree grantor/type: 三重大学
• Date Granted: 2016-03-25
• Date Granted (W3CDTF): 2016-03-25
• Dissertation Number: 甲医学第1770号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1770号
• Text Language Code: eng
• Alias of Author: ヤマダ, レイコ; 山田, 玲子
• Subject Heading: EUS-FNAB; hENT1; chemoradiotherapy; gemcitabine; pancreatic ductal adenocarcinoma
• Target Audience: 一般
• Note (General): application/pdf; Objectives: To clarify whether pretreatment human equilibrative nucleoside transporter (hENTl) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT), and to validate the utility of hENT1 expression using EUS-FNAB samples as a prognostic marker. Methods: We evaluated the relationship between hENT1 expressions assessed by immunohistochemical staining and clinical outcomes in the 51 of 76 PDAC patients who were diagnosed by EUS-FNAB and received preoperative Gem-CRT. Results: The concordance rate of hENT1 expressions was 89.2% (K=0.681). Median survival time (month) in the 51 whole patients and 37 with resection was significantly longer in hENT1 positive than in negative: 25.0 and 30.0 vs. 9.0 and 9.0, respectively. A multivariate analysis confirmed that hENT1 expression was an independent prognostic factor in both whole patients and those with resection. Regardless of T3 and T4, hENT1-positive patients with resection had significantly better prognosis than negative patients , whose prognosis was similar to those without resection. Conclusions: The assessment of hENT1 expression using EUS-FNAB samples prior to Gem-CRT provides important information on PDAC patients who can benefit from curative-intent resection .; 本文 / Gastroenterology and Hepatology, Mie University Graduate School of Medicine; 55p; http://journals.lww.com/pancreasjournal/Fulltext/2016/05000/Human_Equilibrative_Nucleoside_Transporter_1.19.aspx
• DOI: info:doi/10.1097/MPA.0000000000000597; https://doi.org/info:doi/10.1097/MPA.0000000000000597
• Persistent ID (NDL): info:ndljp/pid/10402946; https://dl.ndl.go.jp/pid/10402946
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-08-02T04:31:34+09:00
• Date Created (W3CDTF): 2017-07-04
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://journals.lww.com/pancreasjournal/Fulltext/2016/05000/Human_Equilibrative_Nucleoside_Transporter_1.19.aspx
• Periodical Title (URI): http://hdl.handle.net/10076/00016976; https://mie-u.repo.nii.ac.jp/records/11320
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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