Associations among circulating branched-chain amino acids and tyrosine with muscle volume and glucose metabolism in individuals without diabetes

• Material Type: 博士論文
• Title: Associations among circulating branched-chain amino acids and tyrosine with muscle volume and glucose metabolism in individuals without diabetes
• Author/Editor: Honda, Tatsuro
• Author Heading: Honda, Tatsuro
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2016-03-25
• Publication Date (W3CDTF): 2016-03-25
• Degree grantor/type: 三重大学
• Date Granted: 2016-03-25
• Date Granted (W3CDTF): 2016-03-25
• Dissertation Number: 甲医学第1772号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1772号
• Text Language Code: eng
• Alias of Author: ホンダ, タツロウ; 本田, 達朗
• Subject Heading: insulin resistance; β cell function; fasting blood glucose; Spearman’s test; stepwise multiple regression analysis
• Target Audience: 一般
• Note (General): application/pdf; Background and Aims: Amino acid metabolites including branched chain amino acids (BCAA) and tyrosine (Tyr) affect glucose metabolism. The effects of BCAA on insulin resistance in patients with diabetes seem to conflict with mechanisms determined in animal models and cultured cells. We investigated the physiological effects of BCAA and Tyr on glucose metabolism among healthy community dwellers to clarify the controversy surrounding the effects of BCAA. Participant and methods: We investigated associations among BCAA and Tyr and metabolic parameters in 78 residents (median age, 52 y) of Mie, Japan who did not have pre-diabetes, diabetes, or a BMI > 30 kg/m2. Results: Muscle volume, serum BCAA and Tyr levels were higher in men than in women (n=32 and 46, respectively; all p < 0.0001). Stepwise multiple regression analysis associated BCAA positively with muscle volume (regression coefficient/t/p/ 95%CI=281.8/ 3.7/ 0.0004/ 129.7-433.8), fasting blood glucose (FBG) (12699.4/ 3.22/ 0.0020/ 4830.9-20567.8), fasting immunoreactive insulin (IRI) (8505.1/ 2.75/ 0.0078/ 2322.5-14687.6) and homeostasis model assessment of β cell function (HOMA-β) (893.6/ 2.58/ 0.0122/ 201.8-1585.5), and negatively with the HOMA-insulin resistance (HOMA-IR) (-9294.1/ -2.89/ 0.0052/ -15711.0- -2877.1). Tyr positively correlated with fasting IRI (26.0/ 2.77/ 0.0072/ 7.3-44.7). Conclusions: Insulin sensitivity and muscle volume are positively associated with BCAA in individuals without diabetes. In turn, BCAA correlate with increased FBG and fasting IRI levels. Tyr correlated with fasting IRI, but not with insulin sensitivity.; 本文 / Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine; 27p; https://doi.org/10.1016/j.nut.2015.11.003
• DOI: info:doi/10.1016/j.nut.2015.11.003; https://doi.org/info:doi/10.1016/j.nut.2015.11.003
• Persistent ID (NDL): info:ndljp/pid/10402947; https://dl.ndl.go.jp/pid/10402947
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-08-02T04:31:34+09:00
• Date Created (W3CDTF): 2017-07-04
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): https://doi.org/10.1016/j.nut.2015.11.003
• Periodical Title (URI): http://hdl.handle.net/10076/00016977; https://mie-u.repo.nii.ac.jp/records/11321
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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