Microglia-derived neuregulin expression in psychiatric disorders.

• Material Type: 博士論文
• ISSN: 0889-1591
• Title: Microglia-derived neuregulin expression in psychiatric disorders.
• Volume: 61
• Author/Editor: Ikawa, Daisuke; Makinodan, Manabu; Iwata, Keiko; Ohgidani, Masahiro; Kato, Takahiro A.; Yamashita, Yasunori; Yamamuro, Kazuhiko; Kimoto, Sohei; Toritsuka, Michihiro; Yamauchi, Takahira; Fukami, Shin-ichi; Yoshino, Hiroki; Okumura, Kazuki; Tanaka, Tatsuhide; Wanaka, Akio; Owada, Yuji; Tsujii, Masatsugu; Sugiyama, Toshiro; Tsuchiya, Kenji; Mori, Norio; Hashimoto, Ryota; Matsuzaki, Hideo; Kanba, Shigenobu; Kishimoto, Toshifumi
• Author Heading: Ikawa, Daisuke; Makinodan, Manabu; Iwata, Keiko; Ohgidani, Masahiro; Kato, Takahiro A.; Yamashita, Yasunori; Yamamuro, Kazuhiko; Kimoto, Sohei; Toritsuka, Michihiro; Yamauchi, Takahira; Fukami, Shin-ichi; Yoshino, Hiroki; Okumura, Kazuki; Tanaka, Tatsuhide; Wanaka, Akio; Owada, Yuji; Tsujii, Masatsugu; Sugiyama, Toshiro; Tsuchiya, Kenji; Mori, Norio; Hashimoto, Ryota; Matsuzaki, Hideo; Kanba, Shigenobu; Kishimoto, Toshifumi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2017-03; 61
• Publication Date (W3CDTF): 2017-03
• Alternative Title: 精神疾患におけるマイクログリア由来ニューレグリン発現
• Periodical title: Brain, behavior, and immunity
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2017-06-28
• Date Granted (W3CDTF): 2017-06-28
• Dissertation Number: 乙第1404号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1404号
• Text Language Code: eng
• Subject Heading: Neuregulin; Microglia; Autism spectrum disorder; PBMCs; Cytokine
• Target Audience: 一般
• Note (General): type:Thesis; Several studies have revealed that neuregulins (NRGs) are involved in brain function and psychiatric disorders. While NRGs have been regarded as neuron- or astrocyte-derived molecules, our research has revealed that microglia also express NRGs, levels of which are markedly increased in activated microglia. Previous studies have indicated that microglia are activated in the brains of individuals with autism spectrum disorder (ASD). Therefore, we investigated microglial NRG mRNA expression in multiple lines of mice considered models of ASD. Intriguingly, microglial NRG expression significantly increased in BTBR and socially-isolated mice, while maternal immune activation (MIA) mice exhibited identical NRG expression to controls. Furthermore, we observed a positive correlation between NRG expression in microglia and peripheral blood mononuclear cells (PBMCs) in mice, suggesting that NRG expression in human PBMCs may mirror microglia-derived NRG expression in the human brain. To translate these findings for application in clinical psychiatry, we measured levels of NRG1 splice-variant expression in clinically available PBMCs of patients with ASD. Levels of NRG1 type III expression in PBMCs were positively correlated with impairments in social interaction in children with ASD (as assessed using the Autistic Diagnostic Interview-Revised test: ADI-R). These findings suggest that immune cell-derived NRGs may be implicated in the pathobiology of psychiatric disorders such as ASD.; 博士（医学）・乙第1404号・平成29年6月28日; Copyright © 2017 Elsevier Inc. All rights reserved.; identifier:Brain, behavior, and immunity Vol.61 p.375-385 (2017 Mar); identifier:08891591; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3350; identifier:Brain, behavior, and immunity, 61: 375-385
• DOI: info:doi/10.1016/j.bbi.2017.01.003; https://doi.org/info:doi/10.1016/j.bbi.2017.01.003
• Persistent ID (NDL): info:ndljp/pid/10951944; https://dl.ndl.go.jp/pid/10951944
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-09-02T15:28:24+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3350
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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