Vimentin regulates the invasiveness and is a poor prognostic marker in non-small cell lung cancer

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Vimentin regulates the invasiveness and is a poor prognostic marker in non-small cell lung cancer

Persistent ID (NDL): info:ndljp/pid/10952194

Material type: 博士論文

Author: 田所, 明

Publisher: -

Publication date: 2016-06-28

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Background: Lung cancer cells often express vimentin. However, the function of vimentin in lung cancer cells has not been fully evaluated.Materials an...

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Material Type: 博士論文
Title: Vimentin regulates the invasiveness and is a poor prognostic marker in non-small cell lung cancer
Author/Editor: 田所, 明
Author Heading: 田所, 明
Publication Date: 2016-06-28
Publication Date (W3CDTF): 2016-06-28
Degree grantor/type: 香川大学
Date Granted: 2016-06-28
Date Granted (W3CDTF): 2016-06-28
Dissertation Number: 甲第639号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第639号
Text Language Code: eng
Alias of Author: Tadokoro, Akira
Subject Heading: Lung cancer
invasion
prognosis
vimentin
Target Audience: 一般
Note (General): Background: Lung cancer cells often express vimentin. However, the function of vimentin in lung cancer cells has not been fully evaluated.
Materials and methods: We evaluated the association between vimentin expression in resected non-small cell lung cancer (NSCLC) specimens and prognosis. Short-interfering RNA targeting vimentin and establishment of an invasive cell line by repeated selection of invasive cells using a Matrigel membrane invasion chamber system (MICS) were performed. MICS was used to reveal the relationship between invasiveness and vimentin.
Results: Vimentin positivity was significantly associated with a poor prognosis and was significantly lower in squamous cell carcinoma than in adenocarcinoma. In in vitro experiments, silencing of vimentin reduced invasiveness. Highly invasive cell lines exhibited higher expression of vimentin than did parental cells, and invasive ability was reduced by knockdown of vimentin.
Conclusion: Vimentin expression is associated with prognosis via alteration of the invasive ability of NSCLC cells.
Persistent ID (NDL): info:ndljp/pid/10952194
https://dl.ndl.go.jp/pid/10952194
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-09-02T15:28:24+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/264
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp