D-allose attenuates overexpression of inflammatory cytokines after cerebral ischemia/reperfusion injury in gerbil

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DOI[info:doi/10.1016/j.jstrokecerebrovasdis.2016.01.030]to the data of the same series

D-allose attenuates overexpression of inflammatory cytokines after cerebral ischemia/reperfusion injury in gerbil

Persistent ID (NDL): info:ndljp/pid/10952393

Material type: 博士論文

Author: 篠原, 奈都代

Publisher: -

Publication date: 2016-06-28

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: BackgroundThe present study investigates the effects of d-allose, a rare sugar, on the inflammatory response after transient forebrain ischemia in the...

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Material Type: 博士論文
Title: D-allose attenuates overexpression of inflammatory cytokines after cerebral ischemia/reperfusion injury in gerbil
Author/Editor: 篠原, 奈都代
Author Heading: 篠原, 奈都代
Publication Date: 2016-06-28
Publication Date (W3CDTF): 2016-06-28
Degree grantor/type: 香川大学
Date Granted: 2016-06-28
Date Granted (W3CDTF): 2016-06-28
Dissertation Number: 甲第643号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第643号
Text Language Code: eng
Alias of Author: Shinohara, Natsuyo
Subject Heading: Ischemia
cytokines
d-allose
hyperactivity
inflammation
oxidation
reperfusion
Target Audience: 一般
Note (General): BackgroundThe present study investigates the effects of d-allose, a rare sugar, on the inflammatory response after transient forebrain ischemia in the gerbil and whether it reduces oxidative stress (8-hydroxyl-2′-deoxyguanosine levels) and behavioral deficits.
MethodsTransient forebrain ischemia was induced by occlusion of the bilateral common carotid arteries for 5 minutes. d-Allose was intraperitoneally injected immediately after ischemia (400 mg/kg). Inflammatory cytokines and oxidative damage in the hippocampus and behavioral deficits were examined 3 days after ischemia.
Resultsd-Allose administration reduced ischemia-induced cytokine production, oxidative stress, and behavioral deficits (motor and memory related).
ConclusionsThe present results suggest that d-allose reduces brain injury after transient global ischemia by suppressing inflammation as well as by inhibiting oxidative stress.
DOI: info:doi/10.1016/j.jstrokecerebrovasdis.2016.01.030
https://doi.org/info:doi/10.1016/j.jstrokecerebrovasdis.2016.01.030
Persistent ID (NDL): info:ndljp/pid/10952393
https://dl.ndl.go.jp/pid/10952393
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-09-02T15:28:24+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/268
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp