BMP signaling-related proteins are differentially expressed in the adult cerebellum

• Material Type: 博士論文
• Title: BMP signaling-related proteins are differentially expressed in the adult cerebellum
• Volume: 46
• Author/Editor: Kesavamoorthy, Gandhervin
• Author Heading: Kesavamoorthy, Gandhervin
• Publication Date: 2016
• Publication Date (W3CDTF): 2016
• Alternative Title: BMPシグナル関連タンパク質は成体小脳において多様性を持って発現している
• Periodical title: Journal of Brain Science
• Degree grantor/type: 浜松医科大学
• Date Granted: 2016-09-16
• Date Granted (W3CDTF): 2016-09-16
• Dissertation Number: 甲第736号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 13802甲第736号
• Text Language Code: eng
• Subject Heading: BMP; BMP receptor; chordin; noggin; immunohistochemistry
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; We investigated the distributions of BMP ligands (BMP2, BMP4, BMP5), BMP receptors (BMPR) (BMPRIA, BMPR IB, BMPR II ), BMP antagonists (chordin and noggin) in the adult rat cerebellum. They are differentially expressed throughout the cerebellum. Interestingly, they are more abundantly expressed in the molecular cell layer, where neuronal plastic phenomena, such as long-term depression (LTD) and rebound potentiation (RP) are observed, than in the granule cell layer. In addition, neurons in the cerebellar nuclei also express all of them. We also found differential usages of BMPRIA and BMPRIB in the cerebellum. For example, in the molecular layer, BMPRIA is mainly expressed in the processes of Bergmann glia, while BMPRIB is mainly detected in the dendrites of Purkinje cells. In addition, BMPRIB is expressed in both cell bodies and dendrites of Purkinje cells, while BMPRIA is mainly expressed in cell bodies of Purkinje cells, showing that BMPRIA and BMPRIB are differentially targeted in a Purkinje cell. These data strongly indicate that differential BMP signaling should be needed to keep the proper function of the cerebellum in the adult rat cerebellum.
• DOI: 10.20821/jbs.46.0_70; https://doi.org/10.20821/jbs.46.0_70
• Persistent ID (NDL): info:ndljp/pid/10952453; https://dl.ndl.go.jp/pid/10952453
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-09-02T15:28:24+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/3202; https://hama-med.repo.nii.ac.jp/records/3058
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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