Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission

Persistent ID (NDL): info:ndljp/pid/10993562

Material type: 博士論文

Author: Omoto, Katsuhiroほか

Publisher: MDPI

Publication date: 2015-08-04

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（歯学）

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Note (General)：: Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically med...

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Material Type: 博士論文
ISSN: 2072-6651
Title: Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission
Volume: 7 8
Author/Editor: Omoto, Katsuhiro
Maruhama, Kotaro
Terayama, Ryuji
Yamamoto, Yumiko
Matsushita, Osamu
Sugimoto, Tomosada
Oguma, Keiji
Matsuka, Yoshizo
Author Heading: Omoto, Katsuhiro
Maruhama, Kotaro
Terayama, Ryuji
Yamamoto, Yumiko
Matsushita, Osamu
Sugimoto, Tomosada
Oguma, Keiji
Matsuka, Yoshizo
Publication, Distribution, etc.: MDPI
Publication Date: 2015-08-04
Publication Date (W3CDTF): 2015-08-04
Alternative Title: 知覚神経節内の神経伝達物質による痛み情報伝達
Periodical title: Toxins
Degree grantor/type: 徳島大学
Date Granted: 2017-03-23
Date Granted (W3CDTF): 2017-03-23
Dissertation Number: 甲第3075号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第3075号
Text Language Code: eng
Subject Heading: Botulinum toxin
mechanical allodynia
dorsal root ganglion
transmitter release
Target Audience: 一般
Note (General): Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.
DOI: info:doi/10.3390/toxins7082906
https://doi.org/info:doi/10.3390/toxins7082906
Persistent ID (NDL): info:ndljp/pid/10993562
https://dl.ndl.go.jp/pid/10993562
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-12-04T02:02:48+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/110096
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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