A Pseudomonas aeruginosa Quorum-Sensing autoinducer analog enhances the activity of antibiotics against resistant strains

• Material Type: 博士論文
• ISSN: 1349-6867
• Title: A Pseudomonas aeruginosa Quorum-Sensing autoinducer analog enhances the activity of antibiotics against resistant strains
• Volume: 64 1-2
• Author/Editor: Amoh, Takashi; Murakami, Keiji; Kariyama, Reiko; Hori, Kenji; Irie, Yasuhiko; Viducic, Darija; Hirota, Katsuhiko; Igarashi, Jun; Suga, Hiroaki; Kumon, Hiromi; Miyake, Yoichiro
• Author Heading: Amoh, Takashi; Murakami, Keiji; Kariyama, Reiko; Hori, Kenji; Irie, Yasuhiko; Viducic, Darija; Hirota, Katsuhiko; Igarashi, Jun; Suga, Hiroaki; Kumon, Hiromi; Miyake, Yoichiro
• Publication, Distribution, etc.: Faculty of Medicine Tokushima University
• Publication Date: 2017-02
• Publication Date (W3CDTF): 2017-02
• Alternative Title: 緑膿菌クオラムセンシングオートインデューサー類似化合物は耐性菌に対し抗菌薬の活性を増強する; Enhancement activity of QS autoinducer analog
• Periodical title: The Journal of Medical Investigation
• Degree grantor/type: 徳島大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第3078号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第3078号
• Text Language Code: eng
• Subject Heading: Pseudomonas aeruginosa; CRE; antibiotic resistance
• Target Audience: 一般
• Note (General): In this study, we have investigated the effects of the newly synthesized analog of Pseudomonas aeruginosa quorum-sensing autoinducer named AIA-1 (autoinducer analog) against antibiotic-resistant bacteria. In vitro susceptibility and killing assays for P. aeruginosa PAO1ΔoprD mutant and clinical isolates were performed by using antibiotics and AIA-1. In an in vivo assay, a luminescent carbapenem-resistant strain derived from PAO1ΔoprD was injected into neutropenic ICR mice and bioluminescence images were acquired after the treatment with antibiotics and AIA-1. Additionally, we investigated the effects of the combination use against carbapenem- resistant Enterobacteriaceae (CRE). Using killing assays in P. aeruginosa, the survival rates in the presence of antibiotics and AIA-1 significantly decreased in comparison with those with antibiotics alone. Furthermore, dual treatment of biapenem and AIA-1 was more effective than biapenem alone in a mouse infection model. AIA-1 did not change the MICs in P. aeruginosa, suggesting that AIA-1 acts on the mechanism of antibiotic tolerance. Conversely, the MICs of antibiotics decreased in the presence of AIA-1 in some CRE strains, indicating that AIA-1 may require additional mechanism to act on CRE. In conclusion, AIA-1 may be a potent drug for clinical treatment of infections caused by antibiotic-resistant bacteria.
• DOI: info:doi/10.2152/jmi.64.101; https://doi.org/info:doi/10.2152/jmi.64.101
• Persistent ID (NDL): info:ndljp/pid/10993563; https://dl.ndl.go.jp/pid/10993563
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-12-04T02:02:48+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://repo.lib.tokushima-u.ac.jp/111094
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2019-09-06 再収集