Bone Ingrowth to Ti Fibre Knit Block with High Deformability

• Material Type: 博士論文
• ISSN: 2029-283X
• Title: Bone Ingrowth to Ti Fibre Knit Block with High Deformability
• Volume: 7 4
• Author/Editor: Henmi, Yoko; Naito, Yoshihito; Jimbo, Ryo; Jinno, Yohei; Sekine, Kazumitsu; Hamada, Kenichi
• Author Heading: Henmi, Yoko; Naito, Yoshihito; Jimbo, Ryo; Jinno, Yohei; Sekine, Kazumitsu; Hamada, Kenichi
• Publication, Distribution, etc.: Journal of Oral & Maxillofacial Research
• Publication Date: 2016-12-28
• Publication Date (W3CDTF): 2016-12-28
• Alternative Title: 高い変形能を示すチタン繊維編物内部への骨成長
• Periodical title: Journal of Oral & Maxillofacial Research
• Degree grantor/type: 徳島大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第3081号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第3081号
• Text Language Code: eng
• Subject Heading: biocompatible materials; bone formation; bone substitutes; elastic modulus; histological techniques; titanium
• Target Audience: 一般
• Note (General): Objectives: The objective of this study is to develop a Ti fibre knit block without sintering, and to evaluate its deformability and new bone formation in vivo.Material and Methods: A Ti fibre with a diameter of 150 μm was knitted to fabricate a Ti mesh tube. The mesh tube was compressed in a metal mould to fabricate porous Ti fibre knit blocks with three different porosities of 88%, 69%, and 50%. The elastic modulus and deformability were evaluated using a compression test. The knit block was implanted into bone defects of a rabbit’s hind limb, and new bone formation was evaluated using micro computed tomography (micro-CT) analysis and histological analysis.Results: The knit blocks with 88% porosity showed excellent deformability, indicating potential appropriateness for bone defect filling. Although the porosities of the knit block were different, they indicated similar elastic modulus smaller than 1 GPa. The elastic modulus after deformation increased linearly as the applied compression stress increased. The micro-CT analysis indicated that in the block with 50% porosity new bone filled nearly all of the pore volume four weeks after implantation. In contrast, in the block with 88% porosity, new bone filled less than half of the pore volume even 12 weeks after implantation. The histological analysis also indicated new bone formation in the block.Conclusions: The titanium fibre knit block with high porosity is potentially appropriate for bone defect filling, indicating good bone ingrowth after porosity reduction with applied compression.
• DOI: info:doi/10.5037/jomr.2016.7402; https://doi.org/info:doi/10.5037/jomr.2016.7402
• Persistent ID (NDL): info:ndljp/pid/10993564; https://dl.ndl.go.jp/pid/10993564
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-12-04T02:02:48+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/110102
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp