Detrimental Impact of Vasopressin V2 Receptor Antagonism in a SU5416/Hypoxia/Normoxia-Exposed Rat Model of Pulmonary Arterial Hypertension

• Material Type: 博士論文
• Title: Detrimental Impact of Vasopressin V2 Receptor Antagonism in a SU5416/Hypoxia/Normoxia-Exposed Rat Model of Pulmonary Arterial Hypertension
• Author/Editor: Goto, Itaru
• Author Heading: Goto, Itaru
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2016-07-20
• Publication Date (W3CDTF): 2016-07-20
• Degree grantor/type: 三重大学
• Date Granted: 2016-07-20
• Date Granted (W3CDTF): 2016-07-20
• Dissertation Number: 甲医学第1790号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1790号
• Text Language Code: eng
• Alias of Author: ゴトウ, イタル; 後藤, 至
• Subject Heading: Arginine vasopressin; Pulmonary arterial hypertension; Right ventricular failure; SU5416; Tolvaptan
• Target Audience: 一般
• Note (General): application/pdf; Background: The expression of vasopressin type 2 receptor (V2R) in the lung, and the long-term effects of tolvaptan, a selective V2R antagonist, on pulmonary circulation and right ventricular (RV) remodeling in a pulmonary arterial hypertension (PAH) rat model were evaluated. Methods and Results: Six-week-old male Sprague-Dawley rats were injected subcutaneously with 20 mg/kg of SU5416 and were exposed to hypoxia for 3 weeks followed by re-exposure to normoxia for 7 weeks. These rats showed signs of RV failure and upregulation of V2R and cAMP in the lung tissue at 10 weeks after SU5416 injection. They were then treated with either 0.05% tolvaptan in diet (SUHx+Tolv) or normal diet (SUHx) during 5–10 weeks of SU5416 injection. Normal control rats (Cont) were also used for comparison. SUHx+Tolv had significantly higher pulmonary arterial pressure, more progressive pulmonary arterial remodeling, and more severe myocyte hypertrophy and interstitial myocardial fibrosis in the right ventricle compared with SUHx despite achieving successful preload reduction. Conclusions: Chronic vasopressin V2R antagonism may contribute to the worsening of PAH and the development of RV remodeling.; 本文 / Department of Cardiology and Nephrology, Mie University Graduate School of Medicine; 9p, 3p
• DOI: info:doi/10.1253/circj.CJ-15-1175; https://doi.org/info:doi/10.1253/circj.CJ-15-1175
• Persistent ID (NDL): info:ndljp/pid/10993777; https://dl.ndl.go.jp/pid/10993777
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-12-04T02:02:48+09:00
• Date Created (W3CDTF): 2017-11-07
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00017098; https://mie-u.repo.nii.ac.jp/records/11454
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集