Down-regulation of trefoil factor-3 expression in the rectum is associated with the development of ulcerative colitis-associated cancer

• Material Type: 博士論文
• Title: Down-regulation of trefoil factor-3 expression in the rectum is associated with the development of ulcerative colitis-associated cancer
• Author/Editor: Kondo, Satoru
• Author Heading: Kondo, Satoru
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2016-12-21
• Publication Date (W3CDTF): 2016-12-21
• Degree grantor/type: 三重大学
• Date Granted: 2016-12-21
• Date Granted (W3CDTF): 2016-12-21
• Dissertation Number: 甲医学第1809号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1809号
• Text Language Code: eng
• Alias of Author: コンドウ, サトル; 近藤, 哲
• Subject Heading: trefoil factor-3; ulcerative colitis; colitis-associated cancer; field effect; surveillance
• Target Audience: 一般
• Note (General): application/pdf; Diagnostic markers can facilitate more selective screening and treatment strategies for ulcerative colitis (UC)-associated cancer (UCAC). We analyzed trefoil factor-3 (TFF3), which has an important role in mucosal protection and repair in the gastrointestinal tract, and evaluated its significance for UCAC. We enrolled 145 patients with UC who underwent proctocolectomies including 15 patients (10.8%) with UCAC. We assessed TFF3 expression immunohistochemically in their rectal mucosa and in cancer cells, and compared their expression in UCAC and sporadic colorectal cancer. In testing mucinous granules of goblet cells located in crypts, we found that non-cancerous rectal mucosa of UCAC patients had significantly lower (P < 0.01) mean TFF3 staining scores (4.53 ± 2.36) than did specimens of patients with UC without UCAC (7.21 ± 3.38) or sporadic cancer (7.58 ± 2.72). TFF3 staining score was an independent predictor of UCAC development (odds ratio: 4.32, confidence interval: 1.01–29.9, P = 0.05). These results indicate that low TFF3 expression in rectal mucosa is associated with the development of UCAC. Thus, TFF3 in the rectal mucosa may be a useful biomarker for monitoring patients with UC.; 本文 / Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine; 24p
• Persistent ID (NDL): info:ndljp/pid/10993790; https://dl.ndl.go.jp/pid/10993790
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-12-04T02:02:48+09:00
• Date Created (W3CDTF): 2017-11-07
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00017111; https://mie-u.repo.nii.ac.jp/records/11467
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集