Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer

• Material Type: 博士論文
• Title: Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer
• Author/Editor: Harada, Etsuko
• Author Heading: Harada, Etsuko
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2017-03-24
• Publication Date (W3CDTF): 2017-03-24
• Degree grantor/type: 三重大学
• Date Granted: 2017-03-24
• Date Granted (W3CDTF): 2017-03-24
• Dissertation Number: 甲医学第1824号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1824号
• Text Language Code: eng
• Alias of Author: ハラダ, エツコ; 石井, 栄津子
• Subject Heading: atheroma; chemokines; cytokines; mushrooms; progenitor cells; remodeling; regulatory T cells; vasculitis
• Target Audience: 一般
• Note (General): application/pdf; ABSTRACT The beneficial effects of edible mushrooms for improving chronic intractable diseases have been documented. However, the antiatherogenic activity of the new medicinal mushroom Grifola gargal is unknown. Therefore, we evaluated whether Grifola gargal can prevent or delay the progression of atherosclerosis. Atherosclerosis was induced in ApoE lipoprotein- deficient mice by subcutaneous infusion of angiotensin II. Grifola gargal extract (GGE) was prepared and intraperitoneally injected. The weight of heart and vessels, dilatation/atheroma formation of thoracic and abdominal aorta, the percentage of peripheral granulocytes, and the blood concentration of MCP-1/CCL2 were significantly reduced in mice treated with GGE compared to untreated mice. By contrast, the percentage of regulatory T cells and the plasma concentration of SDF-1/CXCL12 were significantly increased in mice treated with the mushroom extract compared to untreated mice. In vitro, GGE significantly increased the secretion of SDF-1/CXCL12, VEGF, and TGF-b1 from fibroblasts compared to control. This study demonstrated for the first time that Grifola gargal therapy can enhance regulatory T cells and ameliorate atherosclerosis in mice.; 本文 / Department of Immunology, Mie University Graduate School of Medicine; Iwade Research Institute of Mycology; 10p
• DOI: info:doi/10.1089/jmf.2014.3315; https://doi.org/info:doi/10.1089/jmf.2014.3315
• Persistent ID (NDL): info:ndljp/pid/10993802; https://dl.ndl.go.jp/pid/10993802
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-12-04T02:02:48+09:00
• Date Created (W3CDTF): 2017-11-07
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00017123; https://mie-u.repo.nii.ac.jp/records/11479
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集