The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors.

• Material Type: 博士論文
• Title: The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors.
• Author/Editor: Kajiwara, Koichiro; Takata, Shunsuke; To, Thao T; Takara, Kenyo; Hatakeyama, Yuji; Tamaoki, Sachio; Darveau, Richard Peters; Ishikawa, Hiroyuki; Sawa, Yoshihiko
• Author Heading: Kajiwara, Koichiro; Takata, Shunsuke; To, Thao T; Takara, Kenyo; Hatakeyama, Yuji; Tamaoki, Sachio; Darveau, Richard Peters; Ishikawa, Hiroyuki; Sawa, Yoshihiko
• Publication Date: 2017-10-31
• Publication Date (W3CDTF): 2017-10-31
• Alternative Title: The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2017-10-31
• Date Granted (W3CDTF): 2017-10-31
• Dissertation Number: 甲第289号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第289号
• Text Language Code: eng
• Subject Heading: toll-like recepter 2; Porphyromonas gingivalis; LPS; diabetic nephropathy; eritoran
• Target Audience: 一般
• Note (General): Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that periodontal pathogen Porphyromonas gingivalis LPS (Pg-LPS) administration lowered the survival rate of diabetic mice. The present study aims to examine the effect of TLR4 blocking on the suppression of Pg-LPS-induced diabetic nephropathy.; The survival rate and morphological/biochemical features for streptozotocin-induced diabetic mice with Pg-LPS and TLR4 blocker eritoran administration were investigated by reporter gene assay, urine and blood analysis, immunohistochemistry, and real time-PCR.; All of the diabetic mice administered Pg-LPS were euthanized within the survival period of almost all of the diabetic mice. The blood urea nitrogen and creatinine, expression of TLR2 and TGF-b, and type 1 collagen accumulation, in the diabetic mice increased significantly with the Pg-LPS administration. In spite of the limited TLR4 activation with Pg-LPS, the TLR4 blocker eritoran decreased blood urea nitrogen and creatinine, and raised the survival rate of the Pg-LPS-administered diabetic mice slightly. The high expression levels of TLR2, TGF-b, and type 1 collagen in Pg-LPS-administered diabetic mice decreased with eritoran. Nuclear STAT3 which enhances TLR2 expression was detected in the TLR2-expressing glomeruli of diabetic mice. The TLR2 and STAT3 gene expression increased by the Pg-LPS administration but decreased with eritoran. These may suggest that Pg-LPS-induced diabetic nephropathy is mainly dependent on TLR2 signaling on glomerular endothelial cells, and that TLR4 blocker eritoran may play a role to slow the progress of diabetic nephropathy.
• Persistent ID (NDL): info:ndljp/pid/10993988; https://dl.ndl.go.jp/pid/10993988
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-12-04T02:02:48+09:00
• Date Created (W3CDTF): 2017-11-16
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/78
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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