Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus 8

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Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

Persistent ID (NDL): info:ndljp/pid/11008882

Material type: 博士論文

Author: Uddin, Md.Mynほか

Publisher: Springer nature

Publication date: 2017-02-08

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor t...

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Material Type: 博士論文
ISSN: 2041-1723
Title: Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
Volume: 8
Author/Editor: Uddin, Md.Myn
Ohigashi, Izumi
Motosugi, Ryo
Nakayama, Tomomi
Sakata, Mie
Hamazaki, Jun
Nishito, Yasumasa
Rode, Immanuel
Tanaka, Keiji
Takemoto, Tatsuya
Murata, Shigeo
Takahama, Yousuke
Author Heading: Uddin, Md.Myn
Ohigashi, Izumi
Motosugi, Ryo
Nakayama, Tomomi
Sakata, Mie
Hamazaki, Jun
Nishito, Yasumasa
Rode, Immanuel
Tanaka, Keiji
Takemoto, Tatsuya
Murata, Shigeo
Takahama, Yousuke
Publication, Distribution, etc.: Springer nature
Publication Date: 2017-02-08
Publication Date (W3CDTF): 2017-02-08
Alternative Title: Foxn1−β5t転写制御軸は胸腺でのCD8陽性T細胞生成を制御する
Periodical title: Nature Communications
Degree grantor/type: 徳島大学
Date Granted: 2017-09-28
Date Granted (W3CDTF): 2017-09-28
Dissertation Number: 甲第3099号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第3099号
Text Language Code: eng
Subject Heading: 胸腺
胸腺上皮細胞
CD8陽性T細胞
胸腺プロテアソーム
転写制御
Target Audience: 一般
Note (General): The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of β5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8+ T cells. A point mutation in this genome element results in a defect in β5t expression and CD8+ T-cell production in mice. The results reveal a Foxn1-β5t transcriptional axis that governs CD8+ T-cell production in the thymus.
DOI: info:doi/10.1038/ncomms14419
https://doi.org/info:doi/10.1038/ncomms14419
Persistent ID (NDL): info:ndljp/pid/11008882
https://dl.ndl.go.jp/pid/11008882
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2018-01-02T17:18:43+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://repo.lib.tokushima-u.ac.jp/110920
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp