Alternative Title柿由来タンニンは非結核性抗酸菌症(MAC症)のマウスモデルにおいて静菌ならびに抗炎症作用を有する
Note (General)type:Thesis
Nontuberculous mycobacteria (NTM), including Mycobacterium avium complex (MAC), cause opportunistic chronic pulmonary infections. Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. It is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. However, it is hypothesized that condensed tannins might need to be digested and/or fermented into smaller molecules in vivo prior to being absorbed into the body to perform beneficial functions. In this study, we evaluated the effects of soluble persimmon-derived tannins on opportunistic MAC disease. Soluble tannins were hydrolyzed and evaluated by the oxygen radical absorbance capacity (ORAC) method. The ORAC value of soluble tannin hydrolysate was approximately five times greater than that of soluble tannin powder. In addition, soluble tannin hydrolysate exhibited high bacteriostatic activity against MAC in vitro. Furthermore, in an in vivo study, MAC infected mice fed a soluble tannin-containing diet showed significantly higher anti-bacterial activity against MAC and less pulmonary granuloma formation compared with those fed a control diet. Tumor necrosis factor α and inducible nitric oxide synthase levels were significantly lower in lungs of the soluble tannin diet group compared with the control diet group. Moreover, proinflammatory cytokines induced by MAC stimulation of bone marrow-derived macrophages were significantly decreased by addition of soluble tannin hydrolysate. These data suggest that soluble tannin from persimmons might attenuate the pathogenesis of pulmonary NTM infection.
博士（医学）・乙第1408号・平成29年11月24日
Copyright: © 2017 Matsumura et al. This is anopen access article distributed under the terms ofthe Creative Commons Attribution License(http://creativecommons.org/licenses/by/4.0/), whichpermits unrestricted use, distribution, andreproduction in any medium, provided the originalauthor and source are credited.Data Availability Statement: All relevant data arewithin the paper and its Supporting Informationfiles.
identifier:PloS one Vol.12 No.8 Article No.e0183489 (2017 Aug)
identifier:19326203
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3388
identifier:PloS one, 12(8): e0183489
DOIinfo:doi/10.1371/journal.pone.0183489
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2018-02-03T13:25:44+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション