Dietary phosphate exacerbates intestinal inflammation in experimental colitis. 2

• Material Type: 博士論文
• ISSN: 1880-5086
• Title: Dietary phosphate exacerbates intestinal inflammation in experimental colitis.
• Volume: 61 2
• Author/Editor: Sugihara, Kohei; Masuda, Masashi; Nakao, Mari; Abuduli, Maerjianghan; Imi, Yukiko; Oda, Naoko; Okahisa, Toshiya; Yamamoto, Hironori; Takeda, Eiji; Taketani, Yutaka
• Author Heading: Sugihara, Kohei; Masuda, Masashi; Nakao, Mari; Abuduli, Maerjianghan; Imi, Yukiko; Oda, Naoko; Okahisa, Toshiya; Yamamoto, Hironori; Takeda, Eiji; Taketani, Yutaka
• Publication, Distribution, etc.: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
• Publication Date: 2017-09-01
• Publication Date (W3CDTF): 2017-09-01
• Alternative Title: 食餌性リンは大腸炎モデル動物の病態を悪化させる
• Periodical title: Journal of Clinical Biochemistry and Nutrition
• Degree grantor/type: 徳島大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第3090号
• Degree Type: 博士（栄養学）
• Conferring No. (Dissertation): 甲第3090号
• Text Language Code: eng
• Subject Heading: Dietary Pi; DSS-induced colitis; proinflammatory cytokine; NF-κB; ROS
• Target Audience: 一般
• Note (General): The recent widespread consumption of Western diets and food additives worldwide is associated with excessive inorganic phosphate intake. However, researchers have known little about the impact of dietary phosphate intake on the development of inflammatory bowel disease to date. In this study, we investigated the effects of dietary phosphate on intestinal inflammation in experimental colitis. Sprague-Dawley rats were fed different phosphate diets (0.5%, 1.0% and 1.5% phosphate) with or without dextran sulfate sodium. For in vitro study, the effects of phosphate on proinflammatory cytokine induction and reactive oxygen species production in RAW264.7 macrophage were examined. Dietary phosphate exacerbated intestinal inflammation in experimental colitis in a dose-dependent manner, as assessed by the clinical disease activity score, colon length, and histology. Furthermore, the high phosphate diet increased myeloperoxidase activity and proinflammatory cytokine mRNA expression through the activation of nuclear factor κB in the inflamed colon. In addition, high phosphate loading in RAW264.7 cells directly enhanced reactive oxygen species production and proinflammatory cytokine gene expression. Our results demonstrated that the high phosphate diet exacerbated intestinal inflammation in experimental colitis. These findings have important therapeutic implications for inflammatory bowel disease patients.
• DOI: info:doi/10.3164/jcbn.16-117; https://doi.org/info:doi/10.3164/jcbn.16-117
• Persistent ID (NDL): info:ndljp/pid/11050190; https://dl.ndl.go.jp/pid/11050190
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-03-04T07:19:18+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/110124
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp