The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice

• Material Type: 博士論文
• ISSN: 1880-5086
• Title: The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice
• Volume: 62 1
• Author/Editor: Yoshikawa, Ryouhei; Yamamoto, Hironori; Nakahashi, Otoki; Kagawa, Tomohiro; Tajiri, Mari; Nakao, Mari; Fukuda, Shiori; Arai, Hidekazu; Masuda, Masashi; Iwano, Masayuki; Takeda, Eiji; Taketani, Yutaka
• Author Heading: Yoshikawa, Ryouhei; Yamamoto, Hironori; Nakahashi, Otoki; Kagawa, Tomohiro; Tajiri, Mari; Nakao, Mari; Fukuda, Shiori; Arai, Hidekazu; Masuda, Masashi; Iwano, Masayuki; Takeda, Eiji; Taketani, Yutaka
• Publication, Distribution, etc.: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
• Publication Date: 2018-01-01
• Publication Date (W3CDTF): 2018-01-01
• Alternative Title: 年齢に応じた血中活性型ビタミンD濃度, 腎Cyp27b1およびCyp24a1発現に対する食餌性リン反応性の変化には腎α-Klotho遺伝子発現が関連する
• Periodical title: Journal of Clinical Biochemistry and Nutrition
• Degree grantor/type: 徳島大学
• Date Granted: 2017-10-26
• Date Granted (W3CDTF): 2017-10-26
• Dissertation Number: 甲第3119号
• Degree Type: 博士（栄養学）
• Conferring No. (Dissertation): 甲第3119号
• Text Language Code: eng
• Subject Heading: α-Klotho; age-related change; vitamin D metabolism; inorganic phosphate; mice
• Target Audience: 一般
• Note (General): In this study, we investigated the relationship between age-related changes in renal α-Klotho gene expression, vitamin D metabolism and the responsiveness of dietary phosphate in 1, 2 and 13 month-old mice fed a high phosphate (phosphate 1.2%) diet or low phosphate (phosphate 0.02%) diet for 5 days. We found that 1,25-dihydroxyvitamin D levels in plasma were significantly lower in the high phosphate group than the low phosphate group for 1 and 2 month-old mice, but not 13 month-old mice. In addition, in the high phosphate group plasma 1,25-dihydroxyvitamin D levels were decreased in 2 month-old mice relative to 1 month-old mice, but 13 month-old mice had higher levels than 2 month-old mice. In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Interestingly, renal α-Klotho mRNA and protein levels were significant change with age. Furthermore, α-Klotho mRNA expression showed a significant negative correlation with plasma 1,25-dihydroxyvitamin D levels in the high phosphate group. Our results suggest that age-related alterations in renal α-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism.
• DOI: info:doi/10.3164/jcbn.17-20; https://doi.org/info:doi/10.3164/jcbn.17-20
• Persistent ID (NDL): info:ndljp/pid/11063507; https://dl.ndl.go.jp/pid/11063507
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-04-03T03:53:09+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): https://repo.lib.tokushima-u.ac.jp/111009
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp