Comparison of Glucose Area Under the Curve Measured Using Minimally Invasive Interstitial Fluid Extraction Technology with Continuous Glucose Monitoring System in Diabetic Patients

• Material Type: 博士論文
• Title: Comparison of Glucose Area Under the Curve Measured Using Minimally Invasive Interstitial Fluid Extraction Technology with Continuous Glucose Monitoring System in Diabetic Patients
• Author/Editor: Uemura, Mei
• Author Heading: Uemura, Mei
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2017-12-20
• Publication Date (W3CDTF): 2017-12-20
• Degree grantor/type: 三重大学
• Date Granted: 2017-12-20
• Date Granted (W3CDTF): 2017-12-20
• Dissertation Number: 甲医学第1870号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1870号
• Text Language Code: eng
• Alias of Author: ウエムラ, メイ; 上村, 明
• Subject Heading: Continuous glucose monitoring; Diabetes mellitus; Glucose area under the curve; Hyperglycemia; Nocturnal blood; glucose; Post-prandial blood glucose
• Target Audience: 一般
• Note (General): application/pdf; Background: Continuous glucose monitoring (CGM) is reported to be a useful technique, but difficult or inconvenient for some patients and institutions. We are developing a glucose area under the curve (AUC) monitoring system without blood sampling using a minimally invasive interstitial fluid extraction technology (MIET). Here we evaluated the accuracy of interstitial fluid glucose (IG) AUC measured by MIET in patients with diabetes for an extended time interval and the potency of detecting hyperglycemia using CGM data as a reference. Methods: Thirty-eight inpatients with diabetes undergoing CGM were enrolled. MIET comprised a pretreatment step using a plastic microneedle array and glucose accumulation step with a hydrogel patch, which was placed on two sites from 9:00 AM to 5:00 PM or from 10:00 PM to 6:00 AM. IG AUC was calculated by accumulated glucose extracted by hydrogel patches using sodium ion as standard. Results: A significant correlation was observed between the predicted AUC by MIET and CGM in daytime (r=0.76) and nighttime (r=0.82). The optimal cutoff for the IG AUC value of MIET to predict hyperglycemia over 200 mg/dL measured by CGM for 8 hours was 1,067.3 mg・hr/dL with 88.2% sensitivity and 81.5% specificity. Conclusion: We showed that 8-hour IG AUC levels using MIET were valuable in estimating the blood glucose AUC without blood sampling. The results also supported the concept of using this technique for evaluating glucose excursion and for screening hyperglycemia during 8 hours in patients with diabetes at any time of day.; 本文 / Department of Diabetes, Metabolism and Endocrinology, Mie University Graduate School of Medicine; 10p
• DOI: info:doi/10.4093/dmj.2017.41.4.265; https://doi.org/info:doi/10.4093/dmj.2017.41.4.265
• Persistent ID (NDL): info:ndljp/pid/11063537; https://dl.ndl.go.jp/pid/11063537
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-04-03T03:53:09+09:00
• Date Created (W3CDTF): 2018-02-28
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00017510; https://mie-u.repo.nii.ac.jp/records/11872
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集