Morphological study of tooth development in podoplanin-deficient mice.

• Material Type: 博士論文
• Title: Morphological study of tooth development in podoplanin-deficient mice.
• Author/Editor: Takara, Kenyo; Maruo, Naoki; Oka, Kyoko; Kaji, Chiaki; Hatakeyama, Yuji; Sawa, Naruhiko; Kato, Yukinari; Yamashita, Junro; Kojima, Hiroshi; Sawa, Yoshihiko
• Author Heading: Takara, Kenyo; Maruo, Naoki; Oka, Kyoko; Kaji, Chiaki; Hatakeyama, Yuji; Sawa, Naruhiko; Kato, Yukinari; Yamashita, Junro; Kojima, Hiroshi; Sawa, Yoshihiko
• Publication Date: 2018-03-10
• Publication Date (W3CDTF): 2018-03-10
• Alternative Title: Morphological study of tooth development in podoplanin-deficient mice.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2018-03-10
• Date Granted (W3CDTF): 2018-03-10
• Dissertation Number: 甲第290号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第290号
• Text Language Code: eng
• Subject Heading: ポドプラニン; 川本法; コンディショナルノックアウトマウス; Wnt1; 歯; Animals; Bone and Bones; Cells, Cultured; Dentin; Gene Knockout Techniques; Genes, Reporter; Kidney; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neural Crest; Odontogenesis; Organ Specificity; Podocytes; Respiratory System; Stress, Mechanical; Tooth Germ; Transgenes; podoplanin; Kawamoto's film method; conditional knockout mice; tooth
• Target Audience: 一般
• Note (General): Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes, odontoblasts, mesothelial cells, glia cells, and others. It has been reported that podoplanin-RhoA interaction induces cytoskeleton relaxation and cell process stretching in fibroblastic cells and osteocytes, and that podoplanin plays a critical role in type I alveolar cell differentiation. It appears that podoplanin plays a number of different roles in contributing to cell functioning and growth by signaling. However, little is known about the functions of podoplanin in the somatic cells of the adult organism because an absence of podoplanin is lethal at birth by the respiratory failure. In this report, we investigated the tooth germ development in podoplanin-knockout mice, and the dentin formation in podoplanin-conditional knockout mice having neural crest-derived cells with deficiency in podoplanin by the Wnt1 promoter and enhancer-driven Cre recombinase: Wnt1-Cre;PdpnΔ/Δmice. In the Wnt1-Cre;PdpnΔ/Δmice, the tooth and alveolar bone showed no morphological abnormalities and grow normally, indicating that podoplanin is not critical in the development of the tooth and bone.; PLOS ONE
• Persistent ID (NDL): info:ndljp/pid/11092178; https://dl.ndl.go.jp/pid/11092178
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-05-04T12:13:37+09:00
• Date Created (W3CDTF): 2018-04-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171912
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/81
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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