Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus

• Material Type: 博士論文
• ISSN: 0147-9571
• Title: Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus
• Volume: 56
• Author/Editor: Takahashi, Etsuhisa; Indalao, Irene L.; Sawabuchi, Takako; Mizuno, Keiko; Sakai, Satoko; Kimoto, Takashi; Kim, Hyejin; Kido, Hiroshi
• Author Heading: Takahashi, Etsuhisa; Indalao, Irene L.; Sawabuchi, Takako; Mizuno, Keiko; Sakai, Satoko; Kimoto, Takashi; Kim, Hyejin; Kido, Hiroshi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2017-11-23
• Publication Date (W3CDTF): 2017-11-23
• Alternative Title: クラリスロマイシンはインフルエンザAウイルスに感染したマウスにおいて、monocyte chemoattractant protein-1とmatrix metalloproteinase-9の発現誘導を抑制し、肺と心臓における病理学的変化を改善する
• Periodical title: Comparative Immunology, Microbiology and Infectious Diseases
• Degree grantor/type: 徳島大学
• Date Granted: 2018-01-25
• Date Granted (W3CDTF): 2018-01-25
• Dissertation Number: 甲第3122号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3122号
• Text Language Code: eng
• Subject Heading: Matrix metalloproteinase-9; Macrolide; Clarithromycin; Influenza A virus; Multiple organ failure; Evans’ blue extravasation; Influenza A virus infection
• Target Audience: 一般
• Note (General): The influenza A virus (IAV)–cytokine–trypsin/matrix metalloproteinase-9 (MMP-9) cycle is one of the important mechanisms of multiple organ failure in severe influenza. Clarithromycin, a macrolide antibiotic, has immune modulatory and anti-inflammatory effects. We analyzed the effects of clarithromycin on the induction of chemokines, cytokines, MMP-9, trypsin, vascular hyper-permeability and inflammatory aggravation in mice with IAV infection. IAV/Puerto Rico/8/34(H1N1) infection increased the levels of monocyte chemoattractant protein- 1 (MCP-1) and cytokines in serum, and MMP-9 and trypsin in serum and/or the lungs and heart. Clarithromycin significantly suppressed the induction of serum MCP-1 and MMP-9 and vascular hyperpermeability in these organs in the early phase of infection, but did not suppress the induction of trypsin, IL-6 or IFN-γ. Histopathological examination showed that clarithromycin tended to reduce inflammatory cell accumulation in the lungs and heart. These results suggest that clarithromycin suppresses infection-related inflammation and reduces vascular hyperpermeability by suppressing the induction of MCP-1 and MMP-9.
• DOI: info:doi/10.1016/j.cimid.2017.11.002; https://doi.org/info:doi/10.1016/j.cimid.2017.11.002
• Persistent ID (NDL): info:ndljp/pid/11092218; https://dl.ndl.go.jp/pid/11092218
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-05-04T12:13:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/111401
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp