Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma

• Material Type: 博士論文
• ISSN: 2041-4889
• Title: Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma
• Volume: 8
• Author/Editor: Akaiwa, Kei; Namekata, Kazuhiko; Azuchi, Yuriko; Guo, Xiaoli; Kimura, Atsuko; Harada, Chikako; Mitamura, Yoshinori; Harada, Takayuki
• Author Heading: Akaiwa, Kei; Namekata, Kazuhiko; Azuchi, Yuriko; Guo, Xiaoli; Kimura, Atsuko; Harada, Chikako; Mitamura, Yoshinori; Harada, Takayuki
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2017-07-13
• Publication Date (W3CDTF): 2017-07-13
• Alternative Title: Edaravoneによる正常眼圧緑内障モデルマウスの網膜神経節細胞死の抑制; Edaravone prevents normal tension glaucoma
• Periodical title: Cell Death & Disease
• Degree grantor/type: 徳島大学
• Date Granted: 2018-03-23
• Date Granted (W3CDTF): 2018-03-23
• Dissertation Number: 甲第3126号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3126号
• Text Language Code: eng
• Subject Heading: edaravone; NTG; oxidative stress; EAAC1; free radical
• Target Audience: 一般
• Note (General): Glaucoma, one of the leading causes of irreversible blindness, is characterized by progressive degeneration of optic nerves and retinal ganglion cells (RGCs). In the mammalian retina, excitatory amino-acid carrier 1 (EAAC1) is expressed in neural cells, including RGCs. Loss of EAAC1 leads to RGC degeneration without elevated intraocular pressure (IOP) and exhibits glaucomatous pathology including glutamate neurotoxicity and oxidative stress. In the present study, we found that edaravone, a free radical scavenger that is used for treatment of acute brain infarction and amyotrophic lateral sclerosis (ALS), reduces oxidative stress and prevents RGC death and thinning of the inner retinal layer in EAAC1-deficient (KO) mice. In addition, in vivo electrophysiological analyses demonstrated that visual impairment in EAAC1 KO mice was ameliorated with edaravone treatment, clearly establishing that edaravone beneficially affects both histological and functional aspects of the glaucomatous retina. Our findings raise intriguing possibilities for the management of glaucoma by utilizing a widely prescribed drug for the treatment of acute brain infarction and ALS, edaravone, in combination with conventional treatments to lower IOP.
• DOI: info:doi/10.1038/cddis.2017.341; https://doi.org/info:doi/10.1038/cddis.2017.341
• Persistent ID (NDL): info:ndljp/pid/11092341; https://dl.ndl.go.jp/pid/11092341
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-05-04T12:13:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/111432
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp